Accelerated 3D free-breathing high-resolution myocardial <i>T</i><sub>1ρ</sub> mapping at 3 Tesla

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dc.contributor.authorQi, Haikun
dc.contributor.authorLv, Zhenfeng
dc.contributor.authorHu, Junpu
dc.contributor.authorXu, Jian
dc.contributor.authorBotnar, Rene
dc.contributor.authorPrieto, Claudia
dc.contributor.authorHu, Peng
dc.date.accessioned2025-01-20T21:02:53Z
dc.date.available2025-01-20T21:02:53Z
dc.date.issued2022
dc.description.abstractPurpose: To develop a fast free-breathing whole-heart high-resolution myocardial T-1 rho mapping technique with robust spin-lock preparation that can be performed at 3 Tesla.
dc.description.abstractMethods: An adiabatically excited continuous-wave spin-lock module, insensitive to field inhomogeneities, was implemented with an electrocardiogram-triggered low-flip angle spoiled gradient echo sequence with variable-density 3D Cartesian undersampling at a 3 Tesla whole-body scanner. A saturation pulse was performed at the beginning of each cardiac cycle to null the magnetization before T-1 rho preparation. Multiple T-1 rho-weighted images were acquired with T-1 rho preparations with different spin-lock times in an interleaved fashion. Respiratory self-gating approach was adopted along with localized autofocus to enable 3D translational motion correction of the data acquired in each heartbeat. After motion correction, multi-contrast locally low-rank reconstruction was performed to reduce undersampling artifacts. The accuracy and feasibility of the 3D T-1 rho mapping technique was investigated in phantoms and in vivo in 10 healthy subjects compared with the 2D T-1 rho mapping.
dc.description.abstractResults: The 3D T-1 rho mapping technique provided similar phantom T-1 rho measurements in the range of 25-120 ms to the 2D T-1 rho mapping reference over a wide range of simulated heart rates. With the robust adiabatically excited continuous-wave spin-lock preparation, good quality 2D and 3D in vivo T-1 rho-weighted images and T-1 rho maps were obtained. Myocardial T-1 rho values with the 3D T-1 rho mapping were slightly longer than 2D breath-hold measurements (septal T-1 rho: 52.7 +/- 1.4 ms vs. 50.2 +/- 1.8 ms, P < 0.01).
dc.description.abstractConclusion: A fast 3D free-breathing whole-heart T-1 rho mapping technique was proposed for T-1 rho quantification at 3 T with isotropic spatial resolution (2 mm(3)) and short scan time of similar to 4.5 min.
dc.description.funderNational Natural Science Foundation of China
dc.fuente.origenWOS
dc.identifier.doi10.1002/mrm.29417
dc.identifier.eissn1522-2594
dc.identifier.issn0740-3194
dc.identifier.urihttps://doi.org/10.1002/mrm.29417
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/93097
dc.identifier.wosidWOS:000847911300001
dc.issue.numero6
dc.language.isoen
dc.pagina.final2531
dc.pagina.inicio2520
dc.revistaMagnetic resonance in medicine
dc.rightsacceso restringido
dc.subjectfive-breathing
dc.subjectcardiovascular magnetic resonance
dc.subjectspin-lock
dc.subjectT-1 rho mapping
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleAccelerated 3D free-breathing high-resolution myocardial <i>T</i><sub>1ρ</sub> mapping at 3 Tesla
dc.typeartículo
dc.volumen88
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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