Clinical and histopathological features of follicular thyroid cancer in Chile

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dc.contributor.authorDiaz, Rene
dc.contributor.authorDominguez, Jose Miguel
dc.contributor.authorTala, Hernan
dc.contributor.authorOlmos, Roberto
dc.contributor.authorPineda, Pedro
dc.contributor.authorOlivari, Daniela
dc.contributor.authorJimenez, Marcela
dc.contributor.authorMimica, Ximena
dc.contributor.authorLanas, Alejandra
dc.contributor.authorOcares, Gerson
dc.contributor.authorSapunar, Jorge
dc.date.accessioned2025-01-20T20:14:47Z
dc.date.available2025-01-20T20:14:47Z
dc.date.issued2023
dc.description.abstractObjective: Follicular thyroid carcinoma (FTC) is less frequent but has a worse prognosis than papillary carcinoma. The available evidence on pre-operative characteristics of FTC is controversial. Our objective was to characterize the clinical, ultrasound and histopathological presentation of FTC patients treated Chile. Subjects and methods: Retrospective analysis of 97 patients treated for FTC in 6 large centers in Chile. We analyzed their ultrasonographic features and classified the nodules according to ATA risk of malignancy and TI-RADS score, as well as the cytological findings according to the Bethesda system. We described their clinical and histopathological findings at diagnosis and classified their risk of recurrence and mortality according to ATA 2015 recurrence risk category and the eighth edition of the AJCC/UICC staging system, respectively. Results: Median age was 48 years and 73.2% were females. The median diameter was 38.8 mm; only 9.5% of them were microtumors. According to ATA risk of malignancy, 86% of the nodules were low or intermediate suspicious, while 78% were category 3 or 4A nodules according to the TI-RADS. Regarding the Bethesda system, 65.9% had indeterminate cytology (20.6% category III and 45.3% category IV). At histological examination, most were minimally-invasive and angio-invasive tumors with less than 4 foci (54.7% and 28.4% respectively). More than 90% of FTC were unifocal and there was no lymphovascular or extrathyroidal invasion or lymph node involvement. Four patients (4.1%) had distant metastases at diagnosis. Most patients (95%) had stage I or II disease according to the AJCC/UICC staging system, while the risk of recurrence was low at 51.5% when using the ATA risk of recurrence scale. Conclusions: At diagnosis, most FTCs were nodules of low or intermediate suspicion at ultrasound, nearly two thirds had indeterminate cytology according to the Bethesda system, and nearly 50% of them were of low risk of recurrence.
dc.fuente.origenWOS
dc.identifier.doi10.20945/2359-3997000000580
dc.identifier.eissn2359-4292
dc.identifier.issn2359-3997
dc.identifier.urihttps://doi.org/10.20945/2359-3997000000580
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/92220
dc.identifier.wosidWOS:000973573400008
dc.issue.numero3
dc.language.isoen
dc.pagina.final354
dc.pagina.inicio348
dc.revistaArchives of endocrinology metabolism
dc.rightsacceso restringido
dc.subjectThyroid cancer
dc.subjectfollicular
dc.subjectdiagnosis
dc.subjectprognosis
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleClinical and histopathological features of follicular thyroid cancer in Chile
dc.typeartículo
dc.volumen67
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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