Predictors of Survival Outcomes in Non-Metastatic Renal Cell Carcinoma in Latin America and Spain: A Multicentric Analysis

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dc.contributor.authorZequi, Stenio de Cassio
dc.contributor.authorMourao, Thiago Camelo
dc.contributor.authorde Oliveira, Max Moura
dc.contributor.authorCurado, Maria Paula
dc.contributor.authorGueglio, Guilhermo
dc.contributor.authorda Costa, Walter Henriques
dc.contributor.authorZuniga, Alvaro
dc.contributor.authorBengio, Ruben
dc.contributor.authorScorticati, Carlos
dc.contributor.authorRodriguez, Francisco
dc.contributor.authorAutran, Ana Maria
dc.contributor.authorMartinez, Pablo
dc.contributor.authorAmeri, Carlos
dc.contributor.authorMingote, Pablo
dc.contributor.authorSecin, Fernando Pablo
dc.contributor.authorDecia, Ricardo
dc.contributor.authorda Cunha, Isabela Werneck
dc.contributor.authorGuimaraes, Gustavo Cardoso
dc.contributor.authorGlina, Sidney
dc.contributor.authorPalou, Joan
dc.contributor.authorAbreu, Diego
dc.date.accessioned2025-01-23T21:19:50Z
dc.date.available2025-01-23T21:19:50Z
dc.date.issued2019
dc.description.abstractBackground: Renal cell carcinoma (RCC) is a lethal neoplasia. Data from Latin America are scarce, and the distinct ethnic origins of this population could affect predictive or prognostic factors.
dc.description.abstractObjective: We aim to describe a large cohort of non-metastatic renal cell carcinoma, identifying the demographic, clinical, and pathological prognostic factors for survival.
dc.description.abstractMethods: We used a multi-institutional retrospective cohort involving 5,670 patients who underwent radical or partial nephrectomy across seven Latin American countries and Spain from 1980 to 2016. The variables were compared, and Kaplan-Meier curves were used to estimate the overall survival (OS) and cancer-specific survival (CSS).
dc.description.abstractResults: The clear cell subtype represented 66.7% of RCC, followed by chromophobe (13.7%), papillary (5.2%), and others (14.4%). Furthermore, 72.3% of renal masses were <7.0 cm. The 5-year OS and 10-year OS rates were 86.1% and 69.5%, respectively. The 5-year and 10-year CSS rates were 89.9% and 81.8%, respectively. The demographic and clinical predicting factors for OS in the multivariate analysis were age (HR: 2.978), anemia (HR: 1.44), presence of symptoms at presentation (HR: 1.26), Karnofsky score <= 80 (HR: 2.12), and ASA score >= 3 (HR: 1.49). The pathological factors were nodal metastasis (HR: 2.14), pen-renal fat invasion (HR: 2.12), inferior vena cava invasion (HR: 1.61), histologic tumoral necrosis (HR: 1.69), and tumor size >7 cm (HR: 1.64).
dc.description.abstractConclusions: Our findings agreed with those reported for some developed countries. We emphasize that ASA and pen-renal fat invasion as prognostic factors deserve further study. Information regarding microvascular invasion should be regularly incorporated in pathological reports.
dc.fuente.origenWOS
dc.identifier.doi10.3233/KCA-190068
dc.identifier.eissn2468-4570
dc.identifier.issn2468-4562
dc.identifier.urihttps://doi.org/10.3233/KCA-190068
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/101194
dc.identifier.wosidWOS:000664214200006
dc.issue.numero4
dc.language.isoen
dc.pagina.final261
dc.pagina.inicio253
dc.revistaKidney cancer
dc.rightsacceso restringido
dc.subjectRenal cell carcinoma
dc.subjectLatin America
dc.subjectsurvival analysis
dc.subjectnephrectomy
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titlePredictors of Survival Outcomes in Non-Metastatic Renal Cell Carcinoma in Latin America and Spain: A Multicentric Analysis
dc.typeartículo
dc.volumen3
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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