Glycaemia dynamics in gestational diabetes mellitus

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dc.contributor.authorValero, Paola
dc.contributor.authorSalas, Rodrigo
dc.contributor.authorPardo, Fabian
dc.contributor.authorCornejo, Marcelo
dc.contributor.authorFuentes, Gonzalo
dc.contributor.authorVega, Sofia
dc.contributor.authorGrismaldo, Adriana
dc.contributor.authorHillebrands, Jan-Luuk
dc.contributor.authorvan der Beek, Eline M.
dc.contributor.authorvan Goor, Harry
dc.contributor.authorSobrevia, Luis
dc.date.accessioned2025-01-20T21:07:54Z
dc.date.available2025-01-20T21:07:54Z
dc.date.issued2022
dc.description.abstractPregnant women may develop gestational diabetes mellitus (GDM), a disease of pregnancy characterised by maternal and fetal hyperglycaemia with hazardous consequences to the mother, the fetus, and the newborn. Maternal hyperglycaemia in GDM results in fetoplacental endothelial dysfunction. GDM-harmful effects result from chronic and short periods of hyperglycaemia. Thus, it is determinant to keep glycaemia within physiological ranges avoiding short but repetitive periods of hyper or hypoglycaemia. The variation of glycaemia over time is defined as 'glycaemia dynamics'. The latter concept regards with a variety of mechanisms and environmental conditions leading to blood glucose handling. In this review we summarized the different metrics for glycaemia dynamics derived from quantitative, plane distribution, amplitude, score values, variability estimation, and time series analysis. The potential application of the derived metrics from self-monitoring of blood glucose (SMBG) and continuous glucose monitoring (CGM) in the potential alterations of pregnancy outcome in GDM are discussed.
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.bbagen.2022.130134
dc.identifier.eissn1872-8006
dc.identifier.issn0304-4165
dc.identifier.urihttps://doi.org/10.1016/j.bbagen.2022.130134
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/93444
dc.identifier.wosidWOS:000793526100006
dc.issue.numero7
dc.language.isoen
dc.revistaBiochimica et biophysica acta-general subjects
dc.rightsacceso restringido
dc.subjectGlucose monitoring
dc.subjectEndothelial dysfunction
dc.subjectGestational diabetes
dc.subjectpH intracellular
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleGlycaemia dynamics in gestational diabetes mellitus
dc.typeartículo
dc.volumen1866
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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