MR Fingerprinting for Contrast Agent-free and Quantitative Characterization of Focal Liver Lesions

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dc.contributor.authorFujita, Shohei
dc.contributor.authorSano, Katsuhiro
dc.contributor.authorCruz, Gastao
dc.contributor.authorVelasco, Carlos
dc.contributor.authorKawasaki, Hideo
dc.contributor.authorFukumura, Yuki
dc.contributor.authorYoneyama, Masami
dc.contributor.authorSuzuki, Akiyoshi
dc.contributor.authorYamamoto, Kotaro
dc.contributor.authorMorita, Yuichi
dc.contributor.authorArai, Takashi
dc.contributor.authorFukunaga, Issei
dc.contributor.authorUchida, Wataru
dc.contributor.authorKamagata, Koji
dc.contributor.authorAbe, Osamu
dc.contributor.authorKuwatsuru, Ryohei
dc.contributor.authorSaiura, Akio
dc.contributor.authorIkejima, Kenichi
dc.contributor.authorBotnar, Rene
dc.contributor.authorPrieto, Claudia
dc.contributor.authorAoki, Shigeki
dc.date.accessioned2025-01-20T17:15:52Z
dc.date.available2025-01-20T17:15:52Z
dc.date.issued2023
dc.description.abstractPurpose: To evaluate the feasibility of liver MR fingerprinting (MRF) for quantitative characterization and diagnosis of focal liver lesions. Materials and Methods: This single-site, prospective study included 89 participants (mean age, 62 years +/- 15 [SD]; 45 women, 44 men) with various focal liver lesions who underwent MRI between October 2021 and August 2022. The participants underwent routine clinical MRI, non-contrast-enhanced liver MRF, and reference quantitative MRI with a 1.5-T MRI scanner. The bias and repeatability of the MRF measurements were assessed using linear regression, Bland-Altman plots, and coefficients of variation. The diagnostic capability of MRF-derived T1, T2, T2*, proton density fat fraction (PDFF), and a combination of these metrics to distinguish benign from malignant lesions was analyzed according to the area under the receiver operating characteristic curve (AUC). Results: Liver MRF measurements showed moderate to high agreement with reference measurements (intraclass correlation = 0.94, 0.77, 0.45, and 0.61 for T1, T2, T2*, and PDFF, respectively), with underestimation of T2 values (mean bias in lesion = -0.5%, -29%, 5.8%, and -8.2% for T1, T2, T2*, and PDFF, respectively). The median coefficients of variation for repeatability of T1, T2, and T2* values were 2.5% (IQR, 3.6%), 3.1% (IQR, 5.6%), and 6.6% (IQR, 13.9%), respectively. After considering multicollinearity, a combination of MRF measurements showed a high diagnostic performance in differentiating benign from malignant lesions (AUC = 0.92 [95% CI: 0.86, 0.98]). Conclusion: Liver MRF enabled the quantitative characterization of various focal liver lesions in a single breath-hold acquisition.
dc.fuente.origenWOS
dc.identifier.doi10.1148/rycan.230036
dc.identifier.issn2638-616X
dc.identifier.urihttps://doi.org/10.1148/rycan.230036
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/91325
dc.identifier.wosidWOS:001171672600003
dc.issue.numero6
dc.language.isoen
dc.revistaRadiology-imaging cancer
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleMR Fingerprinting for Contrast Agent-free and Quantitative Characterization of Focal Liver Lesions
dc.typeartículo
dc.volumen5
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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