Late motor deficits of Chilean manganese miners: A blinded control study

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dc.contributor.authorHochberg, F
dc.contributor.authorMiller, G
dc.contributor.authorValenzuela, R
dc.contributor.authorMcNelis, S
dc.contributor.authorCrump, KS
dc.contributor.authorCovington, T
dc.contributor.authorValdivia, G
dc.contributor.authorHochberg, B
dc.contributor.authorTrustman, JW
dc.date.accessioned2025-01-21T01:33:52Z
dc.date.available2025-01-21T01:33:52Z
dc.date.issued1996
dc.description.abstractHigh-level chronic manganese (Mn) exposure produces dystonic rigidity and proximal tremor. The late effects of asymptomatic exposure are uncertain. To evaluate hand movements of asymptomatic Chilean miners, we utilized a manual tremormeter (EAP) and a digitizing tablet (MOVEMAP). In Andacollo, Chile, we examined 59 individuals aged >50 years (mean age, 64.4 years). Twenty-seven exposed miners had heavy Mn dust exposure in Mn mines for more than 5 years (mean duration, 20.25 years), ending at least 5 years previously. Thirty-two control miners had never worked in Mn mines or had short-term Mn employment. Tests of resting tremor (EAP Tremormeter, MOVEMAP Steady paradigm), action tremor (MOVEMAP Square paradigm), and repetitive hand movements (EAP Tapping Test and Ortho-kinesimeter) differentiated performance of exposed miners from that of controls. Chronic asymptomatic Mn exposure results in detectable late-life abnormalities of movement.
dc.fuente.origenWOS
dc.identifier.issn0028-3878
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/97482
dc.identifier.wosidWOS:A1996VG59600029
dc.issue.numero3
dc.language.isoen
dc.pagina.final795
dc.pagina.inicio788
dc.revistaNeurology
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleLate motor deficits of Chilean manganese miners: A blinded control study
dc.typeartículo
dc.volumen47
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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