Metamorphic proteins and how to find them

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dc.contributor.authorPorter, Lauren L.
dc.contributor.authorArtsimovitch, Irina
dc.contributor.authorRamirez-Sarmiento, Cesar A.
dc.date.accessioned2025-01-20T16:11:02Z
dc.date.available2025-01-20T16:11:02Z
dc.date.issued2024
dc.description.abstractIn the last two decades, our existing notion that most foldable proteins have a unique native state has been challenged by the discovery of metamorphic proteins, which reversibly interconvert between multiple, sometimes highly dissimilar, native states. As the number of known metamorphic proteins increases, several computational and experimental strategies have emerged for gaining insights about their refolding processes and identifying unknown metamorphic proteins amongst the known proteome. In this review, we describe the current advances in biophysically and functionally ascertaining the structural interconversions of metamorphic proteins and how coevolution can be harnessed to identify novel metamorphic proteins from sequence information. We also discuss the challenges and ongoing efforts in using artificial intelligence-based protein structure prediction methods to discover metamorphic proteins and predict their corresponding three-dimensional structures.
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.sbi.2024.102807
dc.identifier.eissn1879-033X
dc.identifier.issn0959-440X
dc.identifier.urihttps://doi.org/10.1016/j.sbi.2024.102807
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/90246
dc.identifier.wosidWOS:001289785000001
dc.language.isoen
dc.revistaCurrent opinion in structural biology
dc.rightsacceso restringido
dc.subjectMetamorphic proteins
dc.subjectFold-switch
dc.subjectProtein biophysics
dc.subjectCoevolution
dc.subjectProtein structure prediction
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleMetamorphic proteins and how to find them
dc.typeartículo
dc.volumen86
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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