ADENOSINE 5'-TRIPHOSPHATE (ATP), THE NEUROTRANSMITTER IN THE PROSTATIC PORTION OF THE LONGITUDINAL MUSCLE LAYER OF THE RAT VAS-DEFERENS

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dc.contributor.authorDONOSO, MV
dc.contributor.authorBATES, F
dc.contributor.authorMONTIEL, J
dc.contributor.authorHUIDOBROTORO, JP
dc.date.accessioned2025-01-21T01:35:38Z
dc.date.available2025-01-21T01:35:38Z
dc.date.issued1994
dc.description.abstractSuramin (1-100 muM) and alpha,beta-methylene adenosine 5'-triphosphate (AMPCPP, 39 muM), antagonized the motor activity induced by exogenous adenosine 5'-triphosphate (ATP) but not exogenous noradrenaline (NA) in the longitudinal musculature of prostatic (P) and epididymal (E) segments of the rat vas deferens. Likewise, application of these drugs reduced the fast component of the nerve-stimulated contraction in response to a single transmural electrical pulse in E and P. Suramin also blocked in a concentration-dependent fashion, the contractile responses to trains of 1.5, 5, 15 or 30 Hz transmural electrical pulses in P, while it did not affect those in E. AMPCPP obliterated responses to trains of 1.5, 5, and 15 Hz in P, while reducing these responses in E to a significantly lesser extent. Present results strongly support that ATP is the motor transmitter in P, while in E, ATP and NA are likely the co-transmitters responsible for the motor tone.
dc.fuente.origenWOS
dc.identifier.issn0304-3940
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/97704
dc.identifier.wosidWOS:A1994NC11700015
dc.issue.numero1-2
dc.language.isoen
dc.pagina.final62
dc.pagina.inicio59
dc.revistaNeuroscience letters
dc.rightsacceso restringido
dc.subjectSURAMIN
dc.subjectAMPCPP
dc.subjectPURINOCEPTOR DESENSITIZATION
dc.subjectP2X-PURINOCEPTOR
dc.subjectPURINERGIC NEUROTRANSMISSION
dc.subjectRAT VAS DEFERENS
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleADENOSINE 5'-TRIPHOSPHATE (ATP), THE NEUROTRANSMITTER IN THE PROSTATIC PORTION OF THE LONGITUDINAL MUSCLE LAYER OF THE RAT VAS-DEFERENS
dc.typeartículo
dc.volumen169
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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