THE BASOLATERAL DOMAIN OF THE HEPATOCYTE PLASMA-MEMBRANE BEARS RECEPTORS FOR THE CIRCUMSPOROZOITE PROTEIN OF PLASMODIUM-FALCIPARUM SPOROZOITES

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dc.contributor.authorCERAMI, C
dc.contributor.authorFREVERT, U
dc.contributor.authorSINNIS, P
dc.contributor.authorTAKACS, B
dc.contributor.authorCLAVIJO, P
dc.contributor.authorSANTOS, MJ
dc.contributor.authorNUSSENZWEIG, V
dc.date.accessioned2025-01-23T19:22:02Z
dc.date.available2025-01-23T19:22:02Z
dc.date.issued1992
dc.description.abstractMinutes after injection into the circulation, malaria sporozoites enter hepatocytes. The speed and specificity of the invasion process suggest that it is receptor mediated. We show here that recombinant Plasmodium falciparum circumsporozoite protein (CS) binds specifically to regions of the plasma membrane of hepatocytes exposed to circulating blood in the Disse space. No binding has been detected in other organs, or even in other regions of the hepatocyte membrane. The interaction of CS with hepatocytes, as well as sporozoite invasion of HepG2 cells, is inhibited by synthetic peptides representing the evolutionarily conserved region II of CS. We conclude that region II is a sporozoite ligand for hepatocyte receptors localized to the basolateral domain of the plasma membrane. Our findings provide a rational explanation for the target cell specificity of malaria sporozoites.
dc.fuente.origenWOS
dc.identifier.eissn1097-4172
dc.identifier.issn0092-8674
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/98940
dc.identifier.wosidWOS:A1992JN78100016
dc.issue.numero6
dc.language.isoen
dc.pagina.final1033
dc.pagina.inicio1021
dc.revistaCell
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleTHE BASOLATERAL DOMAIN OF THE HEPATOCYTE PLASMA-MEMBRANE BEARS RECEPTORS FOR THE CIRCUMSPOROZOITE PROTEIN OF PLASMODIUM-FALCIPARUM SPOROZOITES
dc.typeartículo
dc.volumen70
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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