EFFECT OF EXOGENOUS SEX STEROIDS UPON THE NUMBER OF GERM-CELLS AND THE GROWTH OF FETAL OVARIES GRAFTED UNDER THE KIDNEY CAPSULE OF ADULT OVARIECTOMIZED HAMSTERS

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dc.contributor.authorARRAU, J
dc.contributor.authorROBLERO, L
dc.contributor.authorCURY, M
dc.contributor.authorGONZALEZ, R
dc.date.accessioned2025-01-23T19:43:59Z
dc.date.available2025-01-23T19:43:59Z
dc.date.issued1983
dc.description.abstractEffect of estradiol (E), progesterone (P) and testosterone propionate (T) upon growth and germ cell population of fetal ovaries transplanted under the kidney capsule of adult ovariectomized hamsters was examined. Fetal ovaries were obtained 15 days postcoitum and the host received daily s.c. injections of E (1 .mu.g/day), P (5 mg/day), T (500 .mu.g/day) or E + P in 0.1 ml oil for 25 days beginning 5 days before grafting. One day after the last injection, the size of the ovary, the germ cell population and plasma steroid levels were assessed. Results of hormone assays indicate that daily steroid administration was able to maintain continuously elevated plasma levels of the corresponding hormone. Interconversions or steroid secretion by the graft, if any, were not reflected in the peripheral circulation. Growth of the graft was stimulated by T and inhibited by P, in comparison with E and oil-treated controls. All germ cells were at the stage of primary-oocyte-forming part of a primordial or growing follicle. Their absolute number was significantly increased by T and E and significantly decreased by P and E + P. The number of oocytes per mm3 of ovary was increased 80, 48 and 40% with E, T and E + P, respectively. In the hamster, exogenous sex steroids given to the host can exert specific effects upon the growth and oocyte population of a grafted fetal ovary. Whether or not the action of steroids upon the graft is a direct one and whether they influenced oogonial mitosis, the evolution of the meiotic prophase or atresia of primary oocytes remains to be determined.
dc.fuente.origenWOS
dc.identifier.issn0022-0752
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/99901
dc.identifier.wosidWOS:A1983RX00300005
dc.issue.numeroDEC
dc.language.isoen
dc.pagina.final42
dc.pagina.inicio33
dc.revistaJournal of embryology and experimental morphology
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleEFFECT OF EXOGENOUS SEX STEROIDS UPON THE NUMBER OF GERM-CELLS AND THE GROWTH OF FETAL OVARIES GRAFTED UNDER THE KIDNEY CAPSULE OF ADULT OVARIECTOMIZED HAMSTERS
dc.typeartículo
dc.volumen78
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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