Functional Interplay of Type-2 Corticotrophin Releasing Factor and Dopamine Receptors in the Basolateral Amygdala-Medial Prefrontal Cortex Circuitry

Simple item page
dc.contributor.authorYarur, H. E.
dc.contributor.authorZegers, J.
dc.contributor.authorVega-Quiroga, I
dc.contributor.authorNovoa, J.
dc.contributor.authorCiruela, F.
dc.contributor.authorAndres, M. E.
dc.contributor.authorGysling, K.
dc.date.accessioned2025-01-20T23:53:51Z
dc.date.available2025-01-20T23:53:51Z
dc.date.issued2021
dc.description.abstractBackground: Basolateral amygdala (BLA) excitatory projections to medial prefrontal cortex (PFC) play a key role controlling stress behavior, pain, and fear. Indeed, stressful events block synaptic plasticity at the BLA-PFC circuit. The stress responses involve the action of corticotrophin releasing factor (CRF) through type 1 and type 2 CRF receptors (CRF1 and CRF2). Interestingly, it has been described that dopamine receptor 1 (D1R) and CRF peptide have a modulatory role of BLA-PFC transmission. However, the participation of CRF1 and CRF2 receptors in BLA-PFC synaptic transmission still is unclear.
dc.description.abstractMethods: We used in vivo microdialysis to determine dopamine and glutamate (GLU) extracellular levels in PFC after BLA stimulation. Immunofluorescence anatomical studies in rat PFC synaptosomes devoid of postsynaptic elements were performed to determine the presence of MR and CRF2 receptors in synaptical nerve endings.
dc.description.abstractResults: Here, we provide direct evidence of the opposite role that CRF receptors exert over dopamine extracellular levels in the PFC. We also show that D1R colocalizes with CRF2 receptors in PFC nerve terminals. Intra-PFC infusion of antisauvagine-30, a CRF2 receptor antagonist, increased PFC GLU extracellular levels induced by BLA activation. Interestingly, the increase in GLU release observed in the presence of antisauvagine-30 was significantly reduced by incubation with SCH23390, a D1R antagonist.
dc.description.abstractConclusion: PFC CRF2 receptor unmasks D1R effect over glutamatergic transmission of the BLA-PFC circuit. Overall, CRF2 receptor emerges as a new modulator of BLA to PFC glutamatergic transmission, thus playing a potential role in emotional disorders.
dc.fuente.origenWOS
dc.identifier.doi10.1093/ijnp/pyaa079
dc.identifier.eissn1469-5111
dc.identifier.issn1461-1457
dc.identifier.urihttps://doi.org/10.1093/ijnp/pyaa079
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/95000
dc.identifier.wosidWOS:000637286400006
dc.issue.numero3
dc.language.isoen
dc.pagina.final228
dc.pagina.inicio221
dc.revistaInternational journal of neuropsychopharmacology
dc.rightsacceso restringido
dc.subjectCRF2 receptor
dc.subjectD1 receptor
dc.subjectglutamatergic transmission
dc.subjectdopaminergic transmission
dc.subjectprefrontal cortex
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleFunctional Interplay of Type-2 Corticotrophin Releasing Factor and Dopamine Receptors in the Basolateral Amygdala-Medial Prefrontal Cortex Circuitry
dc.typeartículo
dc.volumen24
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
Files
Collections
Artículos de revistas