Comparison of the Clinical Expression of Patients with Ankylosing Spondylitis from Europe and Latin America

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dc.contributor.authorBenegas, Mariana
dc.contributor.authorMunoz Gomariz, Elisa
dc.contributor.authorFont, Pilar
dc.contributor.authorBurgos Vargas, Ruben
dc.contributor.authorChaves, Jose
dc.contributor.authorPalleiro, Daniel
dc.contributor.authorMaldonado Cocco, Jose
dc.contributor.authorGutierrez, Miguel
dc.contributor.authorSaenz, Ricardo
dc.contributor.authorSteckmen, Ivan
dc.contributor.authorRillo, Oscar
dc.contributor.authorMulero, Juan
dc.contributor.authorSampaio Barros, Percival
dc.contributor.authorBarcelos, Anabela
dc.contributor.authorVander Cruyssen, Bert
dc.contributor.authorVazquez Mellado, Janitzia
dc.contributor.authorCollantes Estevez, Eduardo
dc.date.accessioned2024-01-10T12:38:07Z
dc.date.available2024-01-10T12:38:07Z
dc.date.issued2012
dc.description.abstractObjective. To compare the clinical, demographic, and serologic characteristics and the treatment of patients diagnosed with ankylosing spondylitis (AS) from Europe (EU) and Latin America (LA).
dc.description.abstractMethods. We included 3439 patients from national registries: the Spanish Registry of Spondyloarthritis (REGISPONSER), the Belgian registry (ASPECT), and the Latin American Registry of Spondyloarthropathies (RESPONDIA). We selected patients with diagnosis of AS who met the modified New York classification criteria. Demographic, clinical, disease activity, functional, and metrological measurement data were recorded. Current treatment was recorded. The population was classified into 2 groups: patients with disease duration < 10 years and those with disease duration >= 10 years. A descriptive and comparative analysis of variables of both groups was carried out.
dc.description.abstractResults. There were 2356 patients in EU group and 1083 in LA group. Prevalence of HLA-B27 was 71% in LA group and 83% in EU group (p < 0.001). We found a greater frequency of peripheral arthritis and enthesitis (p < 0.001) in the LA population; prevalence of arthritis was 57% in LA and 42% in EU, and for enthesitis, 54% and 38%. Except for treatment with anti-tumor necrosis factor (anti-TNF), the use of nonsteroidal antiinflammatory drugs (NSAID), corticosteroids, and disease-modifying antirheumatic drugs (DMARD), and the association of anti-TNF and methotrexate use showed a significant difference (p < 0.001) in the 2 populations.
dc.description.abstractConclusion. The principal differences in the clinical manifestations of patients with AS from EU and LA were the greater frequency of peripheral arthritis and enthesitis in LA group, the higher percentage of HLA-B27 in EU group, and the form of treatment, with a greater use of NSAID, steroids, and DMARD in the LA group. (First Release Nov 15 2012; J Rheumatol 2012;39:2315-20; doi:10.3899/jrheum.110687)
dc.fechaingreso.objetodigital2024-05-30
dc.format.extent6 páginas
dc.fuente.origenWOS
dc.identifier.doi10.3899/jrheum.110687
dc.identifier.eissn1499-2752
dc.identifier.issn0315-162X
dc.identifier.pubmedidMEDLINE:23149388
dc.identifier.urihttps://doi.org/10.3899/jrheum.110687
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/76987
dc.identifier.wosidWOS:000312355400013
dc.information.autorucMedicina;Gutierrez M;S/I;68377
dc.issue.numero12
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final2320
dc.pagina.inicio2315
dc.publisherJ RHEUMATOL PUBL CO
dc.revistaJOURNAL OF RHEUMATOLOGY
dc.rightsacceso restringido
dc.subjectANKYLOSING SPONDYLITIS
dc.subjectCLINICAL EXPRESSION
dc.subjectEUROPE
dc.subjectLATIN AMERICA
dc.subjectMEXICAN MESTIZO
dc.subjectJUVENILE-ONSET
dc.subjectHLA-B27
dc.subjectDISEASE
dc.subjectSUSCEPTIBILITY
dc.subjectHLA
dc.subjectSPONDYLOARTHROPATHIES
dc.subjectPATTERNS
dc.subjectFEATURES
dc.subjectSUBTYPES
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleComparison of the Clinical Expression of Patients with Ankylosing Spondylitis from Europe and Latin America
dc.typeartículo
dc.volumen39
sipa.codpersvinculados68377
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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