Cardiovascular magnetic resonance reveals myocardial involvement in patients with active stage of inflammatory bowel disease

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dc.contributor.authorFenski, Maximilian
dc.contributor.authorAbazi, Endri
dc.contributor.authorGroeschel, Jan
dc.contributor.authorHadler, Thomas
dc.contributor.authorKappelmayer, Diane
dc.contributor.authorKolligs, Frank
dc.contributor.authorPrieto, Claudia
dc.contributor.authorBotnar, Rene
dc.contributor.authorKunze, Karl-Philipp
dc.contributor.authorSchulz-Menger, Jeanette
dc.date.accessioned2025-01-20T16:11:32Z
dc.date.available2025-01-20T16:11:32Z
dc.date.issued2024
dc.description.abstractBackground Active inflammatory bowel disease (A-IBD) but not remission (R-IBD) has been associated with an increased risk of cardiovascular death and hospitalization for heart failure. Objectives Using cardiovascular magnetic resonance (CMR), this study aims to assess adverse myocardial remodeling in patients with IBD in correlation with disease activity. Methods Forty-four IBD patients without cardiovascular disease (24 female, median-age: 39.5 years, 26 A-IBD, 18 R-IBD) and 44 matched healthy volunteers (HV) were prospectively enrolled. The disease stage was determined by endoscopic and patient-reported criteria. Participants underwent CMR for cardiac phenotyping: cine imaging and strain analysis were performed to assess ventricular function. T1 mapping, extracellular volume and late-gadolinium enhanced images were obtained to assess focal and diffuse myocardial fibrosis. Simultaneous T1 and T2 elevation (T1 > 1049.3 ms, T2 > 54 ms) was considered to indicate a myocardial segment was inflamed. Results 16/44 (16.4%) IBD patients described dyspnea on exertion and 10/44 (22.7%) reported chest pain. A-IBD patients showed impaired ventricular function, indicated by reduced global circumferential and radial strain despite preserved left-ventricular ejection fraction. 16% of all IBD patients had focal fibrosis in a non-ischemic pattern. A-IDB patients had increased markers of diffuse left ventricular fibrosis (T1-values: A-IBD: 1022.0 +/- 34.83 ms, R-IBD: 1010.10 +/- 32.88 ms, HV: 990.61 +/- 29.35 ms, p < .01). Significantly more participants with A-IDB (8/26, 30.8%) had at least one inflamed myocardial segment than patients in remission (0/18) and HV (1/44, 2.3%, p < .01). Markers of diffuse fibrosis correlated with disease activity. Conclusion This study, using CMR, provides evidence of myocardial involvement and patterns of adverse left ventricular remodeling in patients with IBD.
dc.fuente.origenWOS
dc.identifier.doi10.1007/s00392-024-02503-5
dc.identifier.eissn1861-0692
dc.identifier.issn1861-0684
dc.identifier.urihttps://doi.org/10.1007/s00392-024-02503-5
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/90277
dc.identifier.wosidWOS:001285986400002
dc.language.isoen
dc.revistaClinical research in cardiology
dc.rightsacceso restringido
dc.subjectCrohn's disease
dc.subjectUlcerative colitis
dc.subjectExtraintestinal manifestation
dc.subjectCardiac remodeling
dc.subjectInflammation
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleCardiovascular magnetic resonance reveals myocardial involvement in patients with active stage of inflammatory bowel disease
dc.typeartículo
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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