Do high MICs predict the outcome in invasive fusariosis?

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dc.contributor.authorNucci, Marcio
dc.contributor.authorJenks, Jeffrey
dc.contributor.authorThompson, George R., III
dc.contributor.authorHoenigl, Martin
dc.contributor.authordos Santos, Marielle Camargo
dc.contributor.authorForghieri, Fabio
dc.contributor.authorRico, Juan Carlos
dc.contributor.authorBonuomo, Valentina
dc.contributor.authorLopez-Soria, Leyre
dc.contributor.authorLass-Florl, Cornelia
dc.contributor.authorCandoni, Anna
dc.contributor.authorGarcia-Vidal, Carolina
dc.contributor.authorCattaneo, Chiara
dc.contributor.authorBuil, Jochem
dc.contributor.authorRabagliati, Ricardo
dc.contributor.authorPia Roiz, Maria
dc.contributor.authorGudiol, Carlota
dc.contributor.authorFracchiolla, Nicola
dc.contributor.authorIsolina Campos-Herrero, Maria
dc.contributor.authorDelia, Mario
dc.contributor.authorFarina, Francesca
dc.contributor.authorFortun, Jesus
dc.contributor.authorNadali, Gianpaolo
dc.contributor.authorSastre, Enric
dc.contributor.authorColombo, Arnaldo L.
dc.contributor.authorPerez Nadales, Elena
dc.contributor.authorAlastruey-Izquierdo, Ana
dc.contributor.authorPagano, Livio
dc.date.accessioned2025-01-20T23:52:03Z
dc.date.available2025-01-20T23:52:03Z
dc.date.issued2021
dc.description.abstractBackground: Invasive fusariosis (IF) affects mostly severely immunocompromised hosts and is associated with poor outcome. Since Fusarium species exhibit high MICs for most antifungal agents, this could explain the poor prognosis. However, a clear-cut correlation between MIC and outcome has not been established.
dc.description.abstractObjective: To evaluate the correlation between MIC and outcome (6 week death rate) in patients with IF.
dc.description.abstractMethods: We performed a multicentre retrospective study of patients with IF who received treatment and had MIC levels determined by EUCAST or CLSI for the drug(s) used during treatment. We compared the MIC50 and MIC distribution among survivors and patients who died within 6 weeks from the diagnosis of IF.
dc.description.abstractResults: Among 88 patients with IF, 74 had haematological diseases. Primary treatment was monotherapy in 52 patients (voriconazole in 27) and combination therapy in 36 patients (liposomal amphotericin B + voriconazole in 23). The MIC50 and range for the five most frequent agents tested were: voriconazole 8 mg/L (range 0.5-64), amphotericin B 2 mg/L (range 0.25-64), posaconazole 16 mg/L (range 0.5-64), itraconazole 32 mg/L (range 4-64), and isayuconazole 32 mg/L (range 8-64). There was no difference in MIC50 and MIC distribution among survivors and patients who died. By contrast, persistent neutropenia and receipt of corticosteroids were strong predictors of 6 week mortality.
dc.description.abstractConclusions: Our study did not show any correlation between MIC and mortality at 6 weeks in patients with IF.
dc.fuente.origenWOS
dc.identifier.doi10.1093/jac/dkaa516
dc.identifier.eissn1460-2091
dc.identifier.issn0305-7453
dc.identifier.urihttps://doi.org/10.1093/jac/dkaa516
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/94879
dc.identifier.wosidWOS:000648949200032
dc.issue.numero4
dc.language.isoen
dc.pagina.final1069
dc.pagina.inicio1063
dc.revistaJournal of antimicrobial chemotherapy
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleDo high MICs predict the outcome in invasive fusariosis?
dc.typeartículo
dc.volumen76
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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