E-2078, A POTENT, SELECTIVE AND STABLE DYNORPHIN ANALOG WITH PREFERENTIAL ACTIVITY FOR THE KAPPA-OPIOID RECEPTOR SUBTYPE ON THE MOUSE VAS-DEFERENS NEUROEFFECTOR JUNCTION

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dc.contributor.authorVALENZUELA, R
dc.contributor.authorTACHIBANA, S
dc.contributor.authorHUIDOBROTORO, JP
dc.date.accessioned2025-01-23T19:22:30Z
dc.date.available2025-01-23T19:22:30Z
dc.date.issued1991
dc.description.abstractThe profile of opioid activity of E-2078, a synthetic stable dynorphin analog, was examined in the mouse vas deferens bioassay and compared to that of methionine enkephalin and nonpeptide kappa agonists in the absence and in the presence of selective antagonists for the mu-, kappa- and delta-opioid receptor subtypes. The inhibitory action of E-2078 and related kappa agonists was specifically and potently antagonized only by norbinaltorphimine, revealing the presence of kappa receptors in this tissue and the predominant kappa activity of E-2078.
dc.fuente.origenWOS
dc.identifier.issn0196-9781
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/99049
dc.identifier.wosidWOS:A1991GW10100007
dc.issue.numero6
dc.language.isoen
dc.pagina.final1214
dc.pagina.inicio1211
dc.revistaPeptides
dc.rightsacceso restringido
dc.subjectDYNORPHIN STABLE ANALOG
dc.subjectE-2078
dc.subjectMOUSE VAS DEFERENS NEUROTRANSMISSION
dc.subjectKAPPA-OPIOID RECEPTOR
dc.subjectNORBINALTORPHIMINE ANTAGONISM
dc.subjectKAPPA-OPIOID AGONIST
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleE-2078, A POTENT, SELECTIVE AND STABLE DYNORPHIN ANALOG WITH PREFERENTIAL ACTIVITY FOR THE KAPPA-OPIOID RECEPTOR SUBTYPE ON THE MOUSE VAS-DEFERENS NEUROEFFECTOR JUNCTION
dc.typeartículo
dc.volumen12
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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