Gestational Diabetes Mellitus Treatment Schemes Modify Maternal Plasma Cholesterol Levels Dependent to Women's Weight: Possible Impact on Feto-Placental Vascular Function

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dc.contributor.authorContreras-Duarte, Susana
dc.contributor.authorCarvajal, Lorena
dc.contributor.authorJesus Garchitorena, Maria
dc.contributor.authorSubiabre, Mario
dc.contributor.authorFuenzalida, Barbara
dc.contributor.authorCantin, Claudette
dc.contributor.authorFarias, Marcelo
dc.contributor.authorLeiva, Andrea
dc.date.accessioned2025-01-23T19:52:41Z
dc.date.available2025-01-23T19:52:41Z
dc.date.issued2020
dc.description.abstractGestational diabetes mellitus (GDM) associates with fetal endothelial dysfunction (ED), which occurs independently of adequate glycemic control. Scarce information exists about the impact of different GDM therapeutic schemes on maternal dyslipidemia and obesity and their contribution to the development of fetal-ED. The aim of this study was to evaluate the effect of GDM-treatments on lipid levels in nonobese (N) and obese (O) pregnant women and the effect of maternal cholesterol levels in GDM-associated ED in the umbilical vein (UV). O-GDM women treated with diet showed decreased total cholesterol (TC) and low-density lipoproteins (LDL) levels with respect to N-GDM ones. Moreover, O-GDM women treated with diet in addition to insulin showed higher TC and LDL levels than N-GDM women. The maximum relaxation to calcitonin gene-related peptide of the UV rings was lower in the N-GDM group compared to the N one, and increased maternal levels of TC were associated with even lower dilation in the N-GDM group. We conclude that GDM-treatments modulate the TC and LDL levels depending on maternal weight. Additionally, increased TC levels worsen the GDM-associated ED of UV rings. This study suggests that it could be relevant to consider a specific GDM-treatment according to weight in order to prevent fetal-ED, as well as to consider the possible effects of maternal lipids during pregnancy.
dc.fuente.origenWOS
dc.identifier.doi10.3390/nu12020506
dc.identifier.eissn2072-6643
dc.identifier.urihttps://doi.org/10.3390/nu12020506
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/100640
dc.identifier.wosidWOS:000522458700233
dc.issue.numero2
dc.language.isoen
dc.revistaNutrients
dc.rightsacceso restringido
dc.subjectGDM
dc.subjectcholesterol
dc.subjectglycemia
dc.subjectGDM treatment
dc.subjectvascular function
dc.subject.ods05 Gender Equality
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa05 Igualdad de género
dc.subject.odspa03 Salud y bienestar
dc.titleGestational Diabetes Mellitus Treatment Schemes Modify Maternal Plasma Cholesterol Levels Dependent to Women's Weight: Possible Impact on Feto-Placental Vascular Function
dc.typeartículo
dc.volumen12
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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