Innate Immune Components That Regulate the Pathogenesis and Resolution of hRSV and hMPV Infections

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dc.catalogadorjca
dc.contributor.authorAndrade, Catalina A.
dc.contributor.authorPacheco, Gaspar A.
dc.contributor.authorGálvez, Nicolas M. S.
dc.contributor.authorSoto, Jorge A.
dc.contributor.authorBueno Ramírez, Susan
dc.contributor.authorKalergis, Alexis M.
dc.date.accessioned2024-02-27T16:02:46Z
dc.date.available2024-02-27T16:02:46Z
dc.date.issued2020
dc.description.abstractThe human respiratory syncytial virus (hRSV) and human Metapneumovirus (hMPV) are two of the leading etiological agents of acute lower respiratory tract infections, which constitute the main cause of mortality in infants. However, there are currently approved vaccines for neither hRSV nor hMPV. Moreover, despite the similarity between the pathology caused by both viruses, the immune response elicited by the host is different in each case. In this review, we discuss how dendritic cells, alveolar macrophages, neutrophils, eosinophils, natural killer cells, innate lymphoid cells, and the complement system regulate both pathogenesis and the resolution of hRSV and hMPV infections. The roles that these cells play during infections by either of these viruses will help us to better understand the illnesses they cause. We also discuss several controversial findings, relative to some of these innate immune components. To better understand the inflammation in the lungs, the role of the respiratory epithelium in the recruitment of innate immune cells is briefly discussed. Finally, we review the main prophylactic strategies and current vaccine candidates against both hRSV and hMPV.
dc.fechaingreso.objetodigital2024-05-17
dc.fuente.origenORCID
dc.identifier.doi10.3390/v12060637
dc.identifier.issn1999-4915
dc.identifier.urihttps://doi.org/10.3390/v12060637
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/81338
dc.identifier.wosidWOS:000551109400001
dc.information.autorucFacultad de Ciencias Biológicas;Andrade Parra, Catalina;S/I;234276
dc.information.autorucFacultad de Ciencias Biológicas;Pacheco Ruidiaz, Gaspar;S/I;1047198
dc.information.autorucFacultad de Ciencias Biológicas;Gálvez Arriagada, Nicolás;0000-0003-2046-7882;215440
dc.information.autorucFacultad de Ciencias Biológicas;Soto Ramírez, Jorge;0000-0003-0335-9759;237269
dc.information.autorucFacultad de Ciencias Biológicas; Bueno Ramírez, Susan Marcela; 0000-0002-7551-8088; 113541
dc.information.autorucFacultad de Ciencias Biológicas;Kalergis, Alexis;0000-0001-7622-5263;90610
dc.issue.numero6
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final46
dc.pagina.inicio1
dc.revistaViruses
dc.rightsacceso abierto
dc.subjecthRSV
dc.subjecthMPV
dc.subjectInnate immune response
dc.subjectVaccines
dc.subjectImmunotherapy
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleInnate Immune Components That Regulate the Pathogenesis and Resolution of hRSV and hMPV Infections
dc.typeartículo
dc.volumen12
sipa.codpersvinculados234276
sipa.codpersvinculados1047198
sipa.codpersvinculados215440
sipa.codpersvinculados237269
sipa.codpersvinculados113541
sipa.codpersvinculados90610
sipa.trazabilidadORCID;2024-01-15
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