Sodium nitroprusside blocks the cat carotid chemosensory inhibition induced by dopamine, but not that by hyperoxia

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dc.contributor.authorIturriaga, R
dc.contributor.authorAlcayaga, J
dc.contributor.authorRey, S
dc.date.accessioned2025-01-21T01:32:36Z
dc.date.available2025-01-21T01:32:36Z
dc.date.issued1998
dc.description.abstractWe studied the effects of the nitric oxide (NO) synthase inhibitor, N omega-nitro-L-arginine methyl ester (L-NAME), and the NO donor, sodium nitroprusside (SNP) on cat chemosensory responses to intravenous injections of NaCN (0.1-100 mu g/kg) and dopamine (0.1-20 mu g/kg), and to hyperoxic ventilation (100% O-2, 60-120 s). Cats were anesthetized with sodium pentobarbitone, paralyzed and artificially ventilated to prevent secondary ventilatory effects. The frequency of chemosensory discharges (f(x)) was recorded from one sectioned carotid sinus nerve. L-NAME (50 mg/kg i.v.) increased basal f(x) and slightly potentiated the responses to NaCN and dopamine. SNP (1-2 mg/kg i.v.) increased basal f(x), but reduced the NaCN-induced increases of f(x) over baseline and the transient f(x) inhibitions induced by dopamine, but not those produced by hyperoxia. Present results indicate that besides the known inhibitory effect of NO on chemosensory responses to low PO2, NO also blocks the chemosensory response to dopamine, leaving hyperoxic responses largely unchanged. (C) 1998 Elsevier Science B.V. All rights reserved.
dc.fuente.origenWOS
dc.identifier.eissn1872-6240
dc.identifier.issn0006-8993
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/97289
dc.identifier.wosidWOS:000075133200004
dc.issue.numero1
dc.language.isoen
dc.pagina.final34
dc.pagina.inicio26
dc.revistaBrain research
dc.rightsacceso restringido
dc.subjectarterial chemoreceptor
dc.subjectcarotid body
dc.subjectcyanide
dc.subjectdopamine
dc.subjecthyperoxia
dc.subjectnitric oxide
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleSodium nitroprusside blocks the cat carotid chemosensory inhibition induced by dopamine, but not that by hyperoxia
dc.typeartículo
dc.volumen799
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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