CLINICAL EXPRESSION OF RHEUMATOID-ARTHRITIS IN CHILEAN PATIENTS

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dc.contributor.authorMASSARDO, L
dc.contributor.authorAGUIRRE, V
dc.contributor.authorGARCIA, ME
dc.contributor.authorCERVILLA, V
dc.contributor.authorNICOVANI, S
dc.contributor.authorGONZALEZ, A
dc.contributor.authorRIVERO, S
dc.contributor.authorJACOBELLI, S
dc.date.accessioned2024-01-10T13:11:48Z
dc.date.available2024-01-10T13:11:48Z
dc.date.issued1995
dc.description.abstractIn populations such as Northern Europeans in which the HLA-DR4 subtypes Dw14 and Dw4 show strong association with rheumatoid arthritis (RA), these alleles and the double allelic dose of the shared epitope are considered severity markers. The clinical expression of RA varies in different populations, which may be determined by variation in the prevalence of these markers. In the present study we analyzed the expression of RA in 112 consecutive Chilean patients and its relation to the prevalence of genetic factors, prompted by our previous observation that DR4 is weakly associated to RA in this population. Mean age was 50 +/- 14 years; 90% were seropositive and 87% were female, with a disease duration of 10 +/- 8 years. Extra-articular manifestations were found in 38% of patients, rheumatoid nodules in 27%, vasculitis in 8%, and Sjogren's syndrome in 29%. Functional capacity (ACR, 1991) I or II: 82%. 15% of patients stopped working. Hand radiographs scored according to Steinbrocker in 89 patients: I, 21%; II, 15%; III, 43%; IV, 21%. In this series, patients with less formal education seemed to have more benign arthritis. In 97 controls and in 65 (56%) RA patients the presence of DRB1 alleles corresponding to DR1 and DR4 serotypes, to DR4-Dw subtypes, and homozygocity, were determined by polymerase chain reaction followed by specific oligonucleotide hybridization. The shared epitope was present in 53% of RA patients and in 30% of controls (P = .0048, odds ratio [OR] = 2.64). A double allelic dose of the epitope was present in 15% of RA patients compared with 4% of controls (P = .026, OR = 4.23). In a subgroup of 31 erosive RA patients we did not find a significant association of disease severity with the shared epitope in a single or double allelic dose. None of the DR4 subtypes that associate with RA in other populations was found significantly more prevalent in our patients. The severity of RA in our study compared with published series was intermediate between British patients with severe RA and Creek patients with milder disease. This may be due to the high prevalence of Dw13*0403 in our population.
dc.fechaingreso.objetodigital16-04-2024
dc.format.extent11 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/S0049-0172(95)80032-8
dc.identifier.issn0049-0172
dc.identifier.pubmedidMEDLINE:8650590
dc.identifier.urihttps://doi.org/10.1016/S0049-0172(95)80032-8
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/78097
dc.identifier.wosidWOS:A1995TK29800006
dc.information.autorucMedicina;Massardo M;S/I;100068
dc.issue.numero3
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final213
dc.pagina.inicio203
dc.publisherW B SAUNDERS CO
dc.revistaSEMINARS IN ARTHRITIS AND RHEUMATISM
dc.rightsacceso restringido
dc.subjectRHEUMATOID ARTHRITIS
dc.subjectIMMUNOGENETICS
dc.subjectCLINICAL EXPRESSION
dc.subjectHLA ANTIGENS
dc.subjectPROGNOSIS
dc.subjectSHARED-EPITOPE HYPOTHESIS
dc.subjectAFRICAN NEGRO POPULATION
dc.subjectWORK DISABILITY
dc.subjectREVISED CRITERIA
dc.subjectGREEK PATIENTS
dc.subjectHLA
dc.subjectMORTALITY
dc.subjectHLA-DR4
dc.subjectDISEASE
dc.subjectASSOCIATION
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleCLINICAL EXPRESSION OF RHEUMATOID-ARTHRITIS IN CHILEAN PATIENTS
dc.typeartículo
dc.volumen25
sipa.codpersvinculados100068
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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