CLINICAL-ASSESSMENT OF SUBDERMAL IMPLANTS OF MEGESTROL ACETATE, D-NORGESTREL, AND NORETHINDRONE AS A LONGTERM CONTRACEPTIVE IN WOMEN

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dc.contributor.authorCROXATTO, HB
dc.contributor.authorDIAZ, S
dc.contributor.authorQUINTEROS, E
dc.contributor.authorSIMONETI, L
dc.contributor.authorKAPLAN, E
dc.contributor.authorRENCORET, R
dc.contributor.authorLEIXELARD, P
dc.contributor.authorMARTINEZ, C
dc.date.accessioned2025-01-23T19:45:13Z
dc.date.available2025-01-23T19:45:13Z
dc.date.issued1975
dc.description.abstractMegestrol acetate (MA), d-norgestrel (d-Ng) and norethindrone (NET) contained in Silastic capsules were implanted under the skin for clinical evaluation as a long-term contraceptive in women. Woman-mo. [1509] of exposure and 4 pregnancies were recorded within the first 12 mo. of use in 135 women who received 6 MA implants. Woman-mo. [1049] and 19 pregnancies were recorded within the first 12 mo. of use in 131 women who received 4 d-Ng implants. After 12 mo. use, the implants were replaced with a new set of capsules. The contraceptive effectiveness of the 2nd and subsequent set of implants was similar to that of the 1st. Five NET implants failed completely to prevent pregnancy and 4 MA implants combined with 2 d-Ng implants were as effective as 6 MA implants. Other doses tested were 5 MA, 3 d-Ng and 4 MA plus 1 d-Ng. They were significantly less effective than the higher doses. No adverse effect upon the outcome of unplanned pregnancies was noted and prompt recovery of fertility was observed after termination of treatment. Ovulation took place in most cycles of women treated with 5 or 6 MA implants, as judged from the occurrence of LH [luteinizing hormone] peak in urine, pregnanediol excretion, changes of cervical mucus, BBT [basal body temperature], and endometrial biopsy. Intermenstrual bleeding was by far the most common side effect recorded. Initially, it occurred in about 30% of the cycles, but the incidence decreased gradually and by the end of the 2nd yr, it was below 10%. Adnexal complications were observed in some of the treatment groups.
dc.fuente.origenWOS
dc.identifier.eissn1879-0518
dc.identifier.issn0010-7824
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/100232
dc.identifier.wosidWOS:A1975BA11900001
dc.issue.numero6
dc.language.isoen
dc.pagina.final627
dc.pagina.inicio615
dc.revistaContraception
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.ods05 Gender Equality
dc.subject.odspa03 Salud y bienestar
dc.subject.odspa05 Igualdad de género
dc.titleCLINICAL-ASSESSMENT OF SUBDERMAL IMPLANTS OF MEGESTROL ACETATE, D-NORGESTREL, AND NORETHINDRONE AS A LONGTERM CONTRACEPTIVE IN WOMEN
dc.typeartículo
dc.volumen12
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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