Hemophagocytic syndrome: Clinical characterization and follow-up of a chilean pediatric cohortSíndrome hemofagocítico: Caracterización clínica y seguimiento de una cohorte pediátrica chilena

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dc.article.number102546
dc.article.number102546
dc.contributor.authorPatricio Astudillo P.
dc.contributor.authorCarla Parejas T.
dc.contributor.authorMaría Angélica Wietstruck P.
dc.contributor.authorPatricio Astudillo P.
dc.contributor.authorPamela Morales M.
dc.contributor.authorKatia Abarca V.
dc.date.accessioned2025-05-01T10:31:49Z
dc.date.available2025-05-01T10:31:49Z
dc.date.issued2021
dc.description.abstract© 2021, Sociedad Chilena de Infectologia. All rights reserved.Background: Hemophagocytic lymphohistiocytosis (HLH) is a severe syndrome, potentially lethal, with a pathological activation of the immune system and an extreme hyperinflammatory response. The etiology is classified in primary HLH (familiar or genetic) and secondary (infectious, oncological, and rheumatological diseases). Aim: To analyze clinical and laboratory characteristics, treatment, and follow-up rates in pediatric patients with HLH. Methods: A pediatric cohort of patients with HLH diagnosis attending in a tertiary hospital between January 2000 to February 2019 was analysed. Results: 23 hospitalized patients were recruited with a median of 36 months of age. The most frequent clinical and laboratory findings were fever, cytopenias, and hyperferritinemia. The most frequent aetiologies were infectious (Epstein Barr virus and citomegalovirus) and rheu-matological diseases. The global mortality was 35%, there was no significant difference between etiologies. Discussion: Considering the high mortality of HLH it is very important to have a high grade of suspicion that allows treating at an early stage. It would be important to determine clinical and laboratory predictors in multicentric studies.
dc.description.funderUniversity of Iowa
dc.description.funderFONDECYT
dc.format.extent15 páginas
dc.fuente.origenScopus
dc.identifier.doi10.4067/S0716-10182021000300423
dc.identifier.eisbn978-84-9880-797-4
dc.identifier.eissn14321262
dc.identifier.isbn978-0-12-817240-7
dc.identifier.issn07161018
dc.identifier.pubmedid33611619
dc.identifier.scieloidS0718-69242020000300109
dc.identifier.scopusidSCOPUS_ID:85112223446
dc.identifier.urihttps://doi.org/10.4067/S0716-10182021000300423
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/103803
dc.identifier.wosidWOS:000619884300001
dc.information.autorucEscuela de Medicina; Wietstruck Pena Maria Angelica; S/I; 100463
dc.information.autorucEscuela de Medicina; Abarca Villaseca Katia; 0000-0003-0404-3887; 70281
dc.issue.numeroe2021050174
dc.language.isoes
dc.nota.accesoSin adjunto
dc.pagina.final431
dc.pagina.inicio423
dc.publisherAcademic Press
dc.relation.ispartof7th Workshop On Educational Innovation In Architecture (JIDA), NOV 14-15, 2019, Madrid, SPAIN
dc.revistaRevista Chilena de Infectologia
dc.rightsAcceso abierto
dc.subjectChildren
dc.subjectFollow-up cohort
dc.subjectHemophagocytic lymphohistiocytosis
dc.subjectPrognosis
dc.subjectRisk factors
dc.subject.ddc510
dc.subject.deweyMatemática física y químicaes_ES
dc.subject.ods02 Zero hunger
dc.subject.odspa02 Hambre cero
dc.titleHemophagocytic syndrome: Clinical characterization and follow-up of a chilean pediatric cohortSíndrome hemofagocítico: Caracterización clínica y seguimiento de una cohorte pediátrica chilena
dc.typeartículo
dc.volumen38
sipa.codpersvinculados100463
sipa.codpersvinculados70281
sipa.indexScopus
sipa.trazabilidadCarga WOS-SCOPUS;01-05-2025
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