Mediterranean diet and psychological well-being intervention to reverse metabolic syndrome in Chile (CHILEMED trial)

Simple item page
dc.article.number101167
dc.catalogadorgjm
dc.contributor.authorEcheverría Errázuriz, Guadalupe
dc.contributor.authorSamith Catalán, Bárbara Patricia
dc.contributor.authorVon Schultzendorff Hoyl, Beatriz Andrea
dc.contributor.authorPinto Manzo, Victoria Sabina
dc.contributor.authorMartínez Cifuentes, Ximena
dc.contributor.authorSara Zaror, Daniela Alejandra
dc.contributor.authorCalzada, Mariana
dc.contributor.authorPacheco Gutiérrez, Josefina
dc.contributor.authorPlaza Paz, Gianella
dc.contributor.authorScott Escorza, Francesca Angelina
dc.contributor.authorRomero Romero, Javiera Constanza
dc.contributor.authorMateo Hernández, Camila
dc.contributor.authorJulio Gonzalez, Maria Verónica
dc.contributor.authorUtreras Mendoza, Yildy
dc.contributor.authorBinder Correa, María Victoria
dc.contributor.authorGutiérrez Medina, Florencia Antonia
dc.contributor.authorRiquelme Stagnaro, María Emilia
dc.contributor.authorCuevas Guzmán, Margarita María
dc.contributor.authorWillatt, Rosario
dc.contributor.authorSánchez González, Omayra Margarita De Jesús
dc.contributor.authorKeilendt Astete, Aracelli Tiare
dc.contributor.authorButron, Patricia
dc.contributor.authorJarufe Calabrese, Alessandra Antonia
dc.contributor.authorHuete Rubio, Isidora Sofia
dc.contributor.authorTobar Bavestrello, Josefina Isidora
dc.contributor.authorMartin. Sofía
dc.contributor.authorAlfaro, Valentina
dc.contributor.authorOlivos Celedón, Matilde
dc.contributor.authorPedrals, Nuria
dc.contributor.authorBitrán Carreño, Marcela
dc.contributor.authorÁvalos, Ivette
dc.contributor.authorRuini, Chiara
dc.contributor.authorRyff, Carol
dc.contributor.authorPérez Pons, Druso Diego
dc.contributor.authorBerkowitz Fiebich, Loni
dc.contributor.authorRigotti Rivera, Attilio
dc.date.accessioned2025-01-24T13:47:51Z
dc.date.available2025-01-24T13:47:51Z
dc.date.issued2023
dc.description.abstractPsychosocial status and lifestyle are key risk factors of non-communicable diseases (NCDs), which, in turn, are main drivers of healthcare costs and morbimortality worldwide, including Chile. Mediterranean diet (MedDiet) is one of the healthiest dietary patterns under study. However, its impact on high-risk conditions, such as metabolic syndrome (MetS), and NCDs outside the Mediterranean Basin remains mostly unexplored. Even though Central Chile has an environment, food production, and culinary traditions comparable to those present in Mediterranean countries, few studies -some with significant methodological limitations- have evaluated the effect of MedDiet on health and/or disease in Chilean subjects. Importantly, a Mediterranean lifestyle is a modus vivendi that integrates physical health with mental and social well-being. Psychological well-being (PWB) is associated with healthy behaviors, positive health outcomes, and longevity, thereby emerging as a novel healthcare goal. We report here an ongoing randomized controlled clinical trial in Chilean patients with MetS seeking to test whether (1) a PWB theory-based intervention facilitates induction to and increases long-term adherence to a locally adapted MedDiet, and (2) a MedDiet intervention -implemented alone or combined with well-being promotion- is more effective at reversing MetS compared to individuals following a low-fat diet without psychological support. The CHILEan MEDiterranean (CHILEMED) diet intervention study is a 1-year trial including patients with MetS living in Chile. Participants will be assigned randomly by a computer-generated random number sequence to one of the three intervention arms: a) low-fat diet as control group, b) MedDiet alone, and c) MedDiet plus well-being support. Patients will be followed-up by individual and/or group online nutritional sessions or phone cal as well as 6- and 12-month in-person re-assessment of medical history, medication use, food intake, PWB, anthropometrics/physical exam, and blood collection for laboratory analysis. The primary outcome of the trial will be the effect of the MedDiet -with or without PWB intervention- on overall reversal of MetS compared to low-fat diet alone. Based on a statistical superiority trial, expected impact, and patient loss, the estimated study sample is 339 subjects (113 individuals per arm in 3 equal-sized groups). Currently, we have enrolled 179 patients, predominantly women, evenly distributed by age (group means ranging from 45.7 to 48,9 years-old), 3/4 are obese with almost all of them showing abdominal obesity, 70% are hypertensive, whereas <10% exhibit diabetes. If findings turn out as expected (e.g., MedDiet -with or without PWB intervention- is better than the low-fat diet for reversion of MetS at 1-year follow-up), CHILEMED will provide further beneficial evidence of the MedDiet on NCD risk conditions beyond the Mediterranean region.
dc.description.funderBanco Santander in Chile
dc.description.funderCOLUN
dc.description.funderMediterranean diet in Chile and academic collaborations with Italian academic institutions
dc.description.funderFONDECYT
dc.description.funderAgencia Nacional de Investigación y Desarrollo
dc.fechaingreso.objetodigital2025-01-22
dc.format.extent9 páginas
dc.fuente.origenScopus
dc.identifier.doi10.1016/j.conctc.2023.101167
dc.identifier.issn2451-8654
dc.identifier.scopusidSCOPUS_ID:85166023459
dc.identifier.urihttps://doi.org/10.1016/j.conctc.2023.101167
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/102052
dc.identifier.wosidWOS:001048097900001
dc.information.autorucEscuela de Medicina; Echeverría Errázuriz, Guadalupe; 0000-0002-2915-0171; 9504
dc.information.autorucEscuela de Medicina; Samith Catalán, Bárbara Patricia; S/I; 208267
dc.information.autorucEscuela de Medicina; Von Schultzendorff Hoyl, Beatriz Andrea; S/I; 1234827
dc.information.autorucEscuela de Medicina; Pinto Manzo, Victoria Sabina; S/I; 215780
dc.information.autorucEscuela de Medicina; Martínez Cifuentes, Ximena; S/I; 1070619
dc.information.autorucDepartamento de Ciencias de la Salud; Sara Zaror, Daniela Alejandra; S/I; 215754
dc.information.autorucEscuela de Medicina; Calzada, Mariana; 0009-0009-2089-9280; 1147776
dc.information.autorucEscuela de Medicina; Pacheco Gutiérrez, Josefina; S/I; 237626
dc.information.autorucEscuela de Medicina; Plaza Paz, Gianella; S/I; 1132065
dc.information.autorucEscuela de Medicina; Scott Escorza, Francesca Angelina; S/I; 1194525
dc.information.autorucEscuela de Medicina; Romero Romero, Javiera Constanza; S/I; 1075385
dc.information.autorucEscuela de Medicina; Mateo Hernández, Camila; S/I; 1183078
dc.information.autorucEscuela de Medicina; Julio Gonzalez, Maria Verónica; S/I; 1038045
dc.information.autorucEscuela de Medicina; Binder Correa, María Victoria; S/I; 1089199
dc.information.autorucEscuela de Medicina; Gutiérrez Medina, Florencia Antonia; S/I; 1135578
dc.information.autorucEscuela de Medicina; Riquelme Stagnaro, María Emilia; S/I; 185178
dc.information.autorucEscuela de Medicina; Cuevas Guzmán, Margarita María; S/I; 1089188
dc.information.autorucEscuela de Medicina; Willatt, Rosario; S/I; 1135621
dc.information.autorucEscuela de Medicina; Sánchez González, Omayra Margarita De Jesús; S/I; 1192966
dc.information.autorucEscuela de Medicina; Keilendt Astete, Aracelli Tiare; S/I; 1046415
dc.information.autorucEscuela de Medicina; Butron, Patricia; S/I; 1192963
dc.information.autorucEscuela de Medicina; Jarufe Calabrese, Alessandra Antonia; S/I; 1089208
dc.information.autorucEscuela de Medicina; Huete Rubio, Isidora Sofia; S/I; 1135613
dc.information.autorucEscuela de Medicina; Tobar Bavestrello, Josefina Isidora; S/I; 1089193
dc.information.autorucS/I; Olivos Celedón, Matilde; S/I; 1247170
dc.information.autorucEscuela de Medicina; Pedrals, Nuria; S/I; 55616
dc.information.autorucEscuela de Medicina; Bitrán Carreño, Marcela; 0000-0001-7647-2109; 450
dc.information.autorucEscuela de Medicina; Pérez Pons, Druso Diego; S/I; 6387
dc.information.autorucEscuela de Medicina; Berkowitz Fiebich, Loni; S/I; 172010
dc.information.autorucEscuela de Medicina; Rigotti Rivera, Attilio; 0000-0002-0495-3525; 68489
dc.language.isoen
dc.nota.accesocontenido completo
dc.revistaContemporary Clinical Trials Communications
dc.rightsacceso abierto
dc.rightsacceso abierto
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 International CC BY-NC-ND 4.0
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectMediterranean diet
dc.subjectMetabolic syndrome
dc.subjectPsychological well-being
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods01 No poverty
dc.subject.ods02 Zero hunger
dc.subject.ods03 Good health and well-being
dc.subject.odspa01 Fin de la pobreza
dc.subject.odspa02 Hambre cero
dc.subject.odspa03 Salud y bienestar
dc.titleMediterranean diet and psychological well-being intervention to reverse metabolic syndrome in Chile (CHILEMED trial)
dc.typeartículo
dc.volumen35
sipa.codpersvinculados9504
sipa.codpersvinculados208267
sipa.codpersvinculados1234827
sipa.codpersvinculados215780
sipa.codpersvinculados1070619
sipa.codpersvinculados215754
sipa.codpersvinculados1147776
sipa.codpersvinculados237626
sipa.codpersvinculados1132065
sipa.codpersvinculados1194525
sipa.codpersvinculados1075385
sipa.codpersvinculados1183078
sipa.codpersvinculados1038045
sipa.codpersvinculados1089199
sipa.codpersvinculados1135578
sipa.codpersvinculados185178
sipa.codpersvinculados1089188
sipa.codpersvinculados1135621
sipa.codpersvinculados1192966
sipa.codpersvinculados1046415
sipa.codpersvinculados1192963
sipa.codpersvinculados1089208
sipa.codpersvinculados1135613
sipa.codpersvinculados1089193
sipa.codpersvinculados1247170
sipa.codpersvinculados55616
sipa.codpersvinculados450
sipa.codpersvinculados6387
sipa.codpersvinculados172010
sipa.codpersvinculados68489
sipa.trazabilidadSCOPUS;2023-08-23
Files
Collections
Artículos de revistas