The association between vegetation size and surgical treatment on 6-month mortality in left-sided infective endocarditis

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dc.contributor.authorFosbol, Emil L.
dc.contributor.authorPark, Lawrence P.
dc.contributor.authorChu, Vivian H.
dc.contributor.authorAthan, Eugene
dc.contributor.authorDelahaye, Francois
dc.contributor.authorFreiberger, Tomas
dc.contributor.authorLamas, Cristiane
dc.contributor.authorMiro, Jose M.
dc.contributor.authorStrahilevitz, Jacob
dc.contributor.authorTribouilloy, Christophe
dc.contributor.authorDurante-Mangoni, Emanuele
dc.contributor.authorPericas, Juan M.
dc.contributor.authorFernandez-Hidalgo, Nuria
dc.contributor.authorNacinovich, Francisco
dc.contributor.authorRizk, Hussein
dc.contributor.authorBarsic, Bruno
dc.contributor.authorGiannitsioti, Efthymia
dc.contributor.authorHurley, John P.
dc.contributor.authorHannan, Margaret M.
dc.contributor.authorWang, Andrew
dc.contributor.authorClara, Liliana
dc.contributor.authorSanchez, Marisa
dc.contributor.authorCasabe, Jose
dc.contributor.authorNacinovich, Francisco
dc.contributor.authorOses, Pablo Fernandez
dc.contributor.authorRonderos, Ricardo
dc.contributor.authorSucari, Adriana
dc.contributor.authorThierer, Jorge
dc.contributor.authorAltclas, Javier
dc.contributor.authorKogan, Silvia
dc.contributor.authorSpelman, Denis
dc.contributor.authorAthan, Eugene
dc.contributor.authorHarris, Owen
dc.contributor.authorKennedy, Karina
dc.contributor.authorTan, Ren
dc.contributor.authorGordon, David
dc.contributor.authorPapanicolas, Lito
dc.contributor.authorKorman, Tony
dc.contributor.authorKotsanas, Despina
dc.contributor.authorDever, Robyn
dc.contributor.authorJones, Phillip
dc.contributor.authorKonecny, Pam
dc.contributor.authorLawrence, Richard
dc.contributor.authorRees, David
dc.contributor.authorRyan, Suzanne
dc.contributor.authorFeneley, Michael P.
dc.contributor.authorHarkness, John
dc.contributor.authorJones, Phillip
dc.contributor.authorRyan, Suzanne
dc.contributor.authorJones, Phillip
dc.contributor.authorRyan, Suzanne
dc.contributor.authorJones, Phillip
dc.contributor.authorPost, Jeffrey
dc.contributor.authorReinbott, Porl
dc.contributor.authorRyan, Suzanne
dc.contributor.authorGattringer, Rainer
dc.contributor.authorWiesbauer, Franz
dc.contributor.authorAndrade, Adriana Ribas
dc.contributor.authorPassos de Brito, Ana Claudia
dc.contributor.authorGuimaraes, Armenio Costa
dc.contributor.authorGrinberg, Max
dc.contributor.authorMansur, Alfredo Jose
dc.contributor.authorSiciliano, Rinaldo Focaccia
dc.contributor.authorVarejao Strabelli, Tania Mara
dc.contributor.authorCampos Vieira, Marcelo Luiz
dc.contributor.authorde Medeiros Tranchesi, Regina Aparecida
dc.contributor.authorPaiva, Marcelo Goulart
dc.contributor.authorFortes, Claudio Querido
dc.contributor.authorRamos, Auristela de Oliveira
dc.contributor.authorWeksler, Clara
dc.contributor.authorFerraiuoli, Giovanna
dc.contributor.authorGolebiovski, Wilma
dc.contributor.authorLamas, Cristiane
dc.contributor.authorKarlowsky, Canada James A.
dc.contributor.authorKeynan, Yoav
dc.contributor.authorMorris, Andrew M.
dc.contributor.authorRubinstein, Ethan
dc.contributor.authorJones, Sandra Braun
dc.contributor.authorGarcia, Patricia
dc.contributor.authorCereceda, M.
dc.contributor.authorFica, Alberto
dc.contributor.authorMella, Rodrigo Montagna
dc.contributor.authorFernandez, Ricardo
dc.contributor.authorFranco, Liliana
dc.contributor.authorGonzalez, Javier
dc.contributor.authorJaramillo, Astrid Natalia
dc.contributor.authorBarsic, Bruno
dc.contributor.authorBukovski, Suzana
dc.contributor.authorKrajinovic, Vladimir
dc.contributor.authorPangercic, Ana
dc.contributor.authorRudez, Igor
dc.contributor.authorVincelj, Josip
dc.contributor.authorFreiberger, Tomas
dc.contributor.authorPol, Jiri
dc.contributor.authorZaloudikova, Barbora
dc.contributor.authorAshour, Zainab
dc.contributor.authorEl Kholy, Amani
dc.contributor.authorMishaal, Marwa
dc.contributor.authorOsama, Dina
dc.contributor.authorRizk, Hussien
dc.contributor.authorAissa, Neijla
dc.contributor.authorAlauzet, Corentine
dc.contributor.authorAlla, Francois
dc.contributor.authorCampagnac, Catherine
dc.contributor.authorDoco-Lecompte, Thanh
dc.contributor.authorSelton-Suty, Christine
dc.contributor.authorCasalta, Jean-Paul
dc.contributor.authorFournier, Pierre-Edouard
dc.contributor.authorHabib, Gilbert
dc.contributor.authorRaoult, Didier
dc.contributor.authorThuny, Franck
dc.contributor.authorDelahaye, Francois
dc.contributor.authorDelahaye, Armelle
dc.contributor.authorVandenesch, Francois
dc.contributor.authorDonal, Erwan
dc.contributor.authorDonnio, Pierre Yves
dc.contributor.authorFlecher, Erwan
dc.contributor.authorMichelet, Christian
dc.contributor.authorRevest, Matthieu
dc.contributor.authorTattevin, Pierre
dc.contributor.authorChevalier, Florent
dc.contributor.authorJeu, Antoine
dc.contributor.authorRemadi, Jean Paul
dc.contributor.authorRusinaru, Dan
dc.contributor.authorTribouilloy, Christophe
dc.contributor.authorBernard, Yvette
dc.contributor.authorChirouze, Catherine
dc.contributor.authorHoen, Bruno
dc.contributor.authorLeroy, Joel
dc.contributor.authorPlesiat, Patrick
dc.contributor.authorNaber, Christoph
dc.contributor.authorNeuerburg, Carl
dc.contributor.authorMazaheri, Bahram
dc.contributor.authorNaber, Christoph
dc.contributor.authorAthanasia, Sophia
dc.contributor.authorDeliolanis, Ioannis
dc.contributor.authorGiamarellou, Helen
dc.contributor.authorThomas, Tsaganos
dc.contributor.authorGiannitsioti, Efthymia
dc.contributor.authorMylona, Elena
dc.contributor.authorPaniara, Olga
dc.contributor.authorPapanicolaou, Konstantinos
dc.contributor.authorPyros, John
dc.contributor.authorSkoutelis, Athanasios
dc.contributor.authorMylona, Elena
dc.contributor.authorPaniara, Olga
dc.contributor.authorPapanikolaou, Konstantinos
dc.contributor.authorPyros, John
dc.contributor.authorSkoutelis, Athanasios
dc.contributor.authorSharma, Gautam
dc.contributor.authorFrancis, Johnson
dc.contributor.authorNair, Lathi
dc.contributor.authorThomas, Vinod
dc.contributor.authorVenugopal, Krishnan
dc.contributor.authorHannan, Margaret M.
dc.contributor.authorHurley, John P.
dc.contributor.authorCahan, Amos
dc.contributor.authorGilon, Dan
dc.contributor.authorIsrael, Sarah
dc.contributor.authorKorem, Maya
dc.contributor.authorStrahilevitz, Jacob
dc.contributor.authorRubinstein, Ethan
dc.contributor.authorStrahilevitz, Jacob
dc.contributor.authorDurante-Mangoni, Emanuele
dc.contributor.authorMattucci, Irene
dc.contributor.authorPinto, Daniela
dc.contributor.authorAgrusta, Federica
dc.contributor.authorSenese, Alessandra
dc.contributor.authorRagone, Enrico
dc.contributor.authorUtili, Riccardo
dc.contributor.authorCecchi, Enrico
dc.contributor.authorDe Rosa, Francesco
dc.contributor.authorForno, Davide
dc.contributor.authorImazio, Massimo
dc.contributor.authorTrinchero, Rita
dc.contributor.authorGrossi, Paolo
dc.contributor.authorLattanzio, Mariangela
dc.contributor.authorToniolo, Antonio
dc.contributor.authorGoglio, Antonio
dc.contributor.authorRaglio, Annibale
dc.contributor.authorRavasio, Veronica
dc.contributor.authorRizzi, Marco
dc.contributor.authorSuter, Fredy
dc.contributor.authorCarosi, Giampiero
dc.contributor.authorMagri, Silvia
dc.contributor.authorSignorini, Liana
dc.contributor.authorKanafani, Zeina
dc.contributor.authorKanj, Souha S.
dc.contributor.authorSharif-Yakan, Ahmad
dc.contributor.authorAbidin, Imran
dc.contributor.authorTamin, Syahidah Syed
dc.contributor.authorRivera Martinez, Eduardo
dc.contributor.authorSoto Nieto, Gabriel Israel
dc.contributor.authorvan der Meer, Jan T. M.
dc.contributor.authorChambers, Stephen
dc.contributor.authorHolland, David
dc.contributor.authorMorris, Arthur
dc.contributor.authorRaymond, Nigel
dc.contributor.authorRead, Kerry
dc.contributor.authorMurdoch, David R.
dc.contributor.authorDragulescu, Stefan
dc.contributor.authorIonac, Adina
dc.contributor.authorMornos, Cristian
dc.contributor.authorButkevich, O. M.
dc.contributor.authorChipigina, Natalia
dc.contributor.authorKirill, Ozerecky
dc.contributor.authorVadim, Kulichenko
dc.contributor.authorVinogradova, Tatiana
dc.contributor.authorEdathodu, Jameela
dc.contributor.authorHalim, Magid
dc.contributor.authorLiew, Yee-Yun
dc.contributor.authorTan, Ru-San
dc.contributor.authorLejko-Zupanc, Tatjana
dc.contributor.authorLogar, Mateja
dc.contributor.authorMueller-Premru, Manica
dc.contributor.authorCommerford, Patrick
dc.contributor.authorCommerford, Anita
dc.contributor.authorDeetlefs, Eduan
dc.contributor.authorHansa, Cass
dc.contributor.authorNtsekhe, Mpiko
dc.contributor.authorAlmela, Manuel
dc.contributor.authorArmero, Yolanda
dc.contributor.authorAzqueta, Manuel
dc.contributor.authorCastaneda, Ximena
dc.contributor.authorCervera, Carlos
dc.contributor.authorFalces, Carlos
dc.contributor.authorGarcia de-la-Maria, Cristina
dc.contributor.authorFita, Guillermina
dc.contributor.authorGatell, Jose M.
dc.contributor.authorHeras, Magda
dc.contributor.authorLlopis, Jaime
dc.contributor.authorMarco, Francesc
dc.contributor.authorMestres, Carlos A.
dc.contributor.authorMiro, Jose M.
dc.contributor.authorMoreno, Asuncion
dc.contributor.authorNinot, Salvador
dc.contributor.authorPare, Carlos
dc.contributor.authorPericas, Juan M.
dc.contributor.authorRamirez, Jose
dc.contributor.authorRovira, Irene
dc.contributor.authorSitges, Marta
dc.contributor.authorAnguera, Ignasi
dc.contributor.authorFont, Bernat
dc.contributor.authorGuma, Joan Raimon
dc.contributor.authorBermejo, Javier
dc.contributor.authorBouza, Emilio
dc.contributor.authorGarcia Fernandez, Miguel Angel
dc.contributor.authorGonzalez-Ramallo, Victor
dc.contributor.authorMarin, Mercedes
dc.contributor.authorMunoz, Patricia
dc.contributor.authorPedromingo, Miguel
dc.contributor.authorRoda, Jorge
dc.contributor.authorRodriguez-Creixems, Marta
dc.contributor.authorSolis, Jorge
dc.contributor.authorAlmirante, Benito
dc.contributor.authorFernandez-Hidalgo, Nuria
dc.contributor.authorTornos, Pilar
dc.contributor.authorde Alarcon, Aristides
dc.contributor.authorParra, Ricardo
dc.contributor.authorAlestig, Eric
dc.contributor.authorJohansson, Magnus
dc.contributor.authorOlaison, Lars
dc.contributor.authorSnygg-Martin, Ulrika
dc.contributor.authorPachirat, Orathai
dc.contributor.authorPachirat, Pimchitra
dc.contributor.authorPussadhamma, Burabha
dc.contributor.authorSenthong, Vichai
dc.contributor.authorCasey, Anna
dc.contributor.authorElliott, Tom
dc.contributor.authorLambert, Peter
dc.contributor.authorWatkin, Richard
dc.contributor.authorEyton, Christina
dc.contributor.authorKlein, John L.
dc.contributor.authorBradley, Suzanne
dc.contributor.authorKauffman, Carol
dc.contributor.authorBedimo, Roger
dc.contributor.authorChu, Vivian H.
dc.contributor.authorCorey, G. Ralph
dc.contributor.authorCrowley, Anna Lisa
dc.contributor.authorDouglas, Pamela
dc.contributor.authorDrew, Laura
dc.contributor.authorFowler, Vance G.
dc.contributor.authorHolland, Thomas
dc.contributor.authorLalani, Tahaniyat
dc.contributor.authorMudrick, Daniel
dc.contributor.authorSamad, Zaniab
dc.contributor.authorSexton, Daniel
dc.contributor.authorStryjewski, Martin
dc.contributor.authorWoods, Christopher W.
dc.contributor.authorLerakis, Stamatios
dc.contributor.authorCantey, Robert
dc.contributor.authorSteed, Lisa
dc.contributor.authorWray, Dannah
dc.contributor.authorDickerman, Stuart A.
dc.contributor.authorBonilla, Hector
dc.contributor.authorDiPersio, Joseph
dc.contributor.authorSalstrom, Sara-Jane
dc.contributor.authorBaddley, John
dc.contributor.authorPatel, Mukesh
dc.contributor.authorPeterson, Gail
dc.contributor.authorStancoven, Amy
dc.contributor.authorLevine, Donald
dc.contributor.authorRiddle, Jonathan
dc.contributor.authorRybak, Michael
dc.date.accessioned2025-01-23T21:10:29Z
dc.date.available2025-01-23T21:10:29Z
dc.date.issued2019
dc.description.abstractAims In left-sided infective endocarditis (IE), a large vegetation >10mm is associated with higher mortality, yet it is unknown whether surgery during the acute phase opposed to medical therapy is associated with improved survival. We assessed the association between surgery and 6-month mortality as related to vegetation size.
dc.description.abstractMethods and results Patients with definite, left-sided IE (2008-2012) from The International Collaboration on Endocarditis prospective, multinational registry were included. We compared clinical characteristics and 6-month mortality (by Cox regression with inverse propensity of treatment weighting) between patients with vegetation size <= 10mm vs. >10mm in maximum length by surgical treatment strategy. A total of 1006 patients with left sided IE were included; 422 with a vegetation size <= 10mm (median age 66.0 years, 33% women) and 584 (median age 58.4 years, 34% women) patients with a large vegetation >10 mm. Operative risk by STS-IE score was similar between groups. Embolic events occurred in 28.4% vs. 44.3% (P < 0.001), respectively. Patients with a vegetation >10mm was associated with higher 6-month mortality (25.1% vs. 19.4% for small vegetation, P = 0.035). However, after propensity adjustment, the association with higher mortality persisted only in patients with a large vegetation >10mm vs. <= 10 mm: hazard ratio (HR) 1.55 (1.27-1.90); but only in patients with large vegetation managed medically [HR 1.86 (1.48-2.34)] rather than surgically [HR 1.01 (0.69-1.49)].
dc.description.abstractConclusion Left-sided IE with vegetation size >10mm was associated with an increased mortality at 6 months in this observational study but was dependent on treatment strategy. For patients with large vegetation undergoing surgical treatment, survival was similar to patients with smaller vegetation size.
dc.fuente.origenWOS
dc.identifier.doi10.1093/eurheartj/ehz204
dc.identifier.eissn1522-9645
dc.identifier.issn0195-668X
dc.identifier.urihttps://doi.org/10.1093/eurheartj/ehz204
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/100849
dc.identifier.wosidWOS:000490141900019
dc.issue.numero27
dc.language.isoen
dc.pagina.final2251
dc.pagina.inicio2243
dc.revistaEuropean heart journal
dc.rightsacceso restringido
dc.subjectInfective endocarditis
dc.subjectVegetation size
dc.subjectSurgery
dc.subjectAntibiotics
dc.subjectOutcomes
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleThe association between vegetation size and surgical treatment on 6-month mortality in left-sided infective endocarditis
dc.typeartículo
dc.volumen40
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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