POTENTIATION OF DIACYLGLYCEROL-ACTIVATED PROTEIN KINASE-C BY ACYL-COENZYME A THIOESTERS OF HYPOLIPEMIC DRUGS

Simple item page
dc.contributor.authorBRONFMAN, M
dc.contributor.authorORELLANA, A
dc.contributor.authorMORALES, MN
dc.contributor.authorBIERI, F
dc.contributor.authorWAECHTER, F
dc.contributor.authorSTAUBLI, W
dc.contributor.authorBENTLEY, P
dc.date.accessioned2025-01-23T19:24:04Z
dc.date.available2025-01-23T19:24:04Z
dc.date.issued1989
dc.description.abstractAcyl-Coenzyme A thioesters of the hypolipidaemic and cancerinogenic peroxisome proliferators clofibric acid, nafenopin, ciprofibrate, benzafibrate and tibric acid were found to greatly increase the activity of rat brain protein kinase C. Maximal activation required the simultaneous presence of Ca2+, phosphatidylserine and diolein, thus differentiating their action from that of other tumor promoters such as phorbol esters. Under similar conditions the unesterified drugs were comparatively ineffective. Similar results were obtained using the rat liver enzyme. The data suggest that acyl-coenzyme A thioesters of hypolipidaemic drugs, may play a role in the induction of liver tumors by these compounds, through the potentiation of protein kinase C.
dc.fuente.origenWOS
dc.identifier.eissn1090-2104
dc.identifier.issn0006-291X
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/99304
dc.identifier.wosidWOS:A1989T956800023
dc.issue.numero3
dc.language.isoen
dc.pagina.final1031
dc.pagina.inicio1026
dc.revistaBiochemical and biophysical research communications
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titlePOTENTIATION OF DIACYLGLYCEROL-ACTIVATED PROTEIN KINASE-C BY ACYL-COENZYME A THIOESTERS OF HYPOLIPEMIC DRUGS
dc.typeartículo
dc.volumen159
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
Files
Collections
Artículos de revistas