MOTOR-NERVE REGULATES MUSCLE EXTRACELLULAR-MATRIX PROTEOGLYCAN EXPRESSION

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dc.contributor.authorFADIC, R
dc.contributor.authorBRANDAN, E
dc.contributor.authorINESTROSA, NC
dc.date.accessioned2025-01-23T19:23:00Z
dc.date.available2025-01-23T19:23:00Z
dc.date.issued1990
dc.description.abstractDenervation of rat leg muscles caused a 2-3 fold increase in 35S-sulfate and 3H-glucosamine incorporation into proteoglycans of the muscle extracellular matrix. The size of the proteoglycans and the glycosaminoglycan chain length and degree of sulfation were unchanged. Because the rate of degradation of proteolyglycans was also unchanged by denervation, we infer that denervation increases proteoglycan synthesis. Muscle reinnervation restored the original rate of synthesis of proteoglycans. Paralysis of innervated muscle caused increased incorporation of sulfate comparable to that seen in denervation. Thus motor nerve activity appears to regulate the level of proteoglycans in the muscle extracellular matrix.
dc.fuente.origenWOS
dc.identifier.eissn1529-2401
dc.identifier.issn0270-6474
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/99145
dc.identifier.wosidWOS:A1990EG88500005
dc.issue.numero11
dc.language.isoen
dc.pagina.final3523
dc.pagina.inicio3516
dc.revistaJournal of neuroscience
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleMOTOR-NERVE REGULATES MUSCLE EXTRACELLULAR-MATRIX PROTEOGLYCAN EXPRESSION
dc.typeartículo
dc.volumen10
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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