β-amyloid oligomers affect the structure and function of the postsynaptic region: Role of the Wnt signaling pathway

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dc.catalogadorgrr
dc.contributor.authorDinamarca Ceballos, Margarita Constanza
dc.contributor.authorColombres Raby, Marcela
dc.contributor.authorCerpa Nebott ,Waldo Francisco
dc.contributor.authorBonansco, Christian
dc.contributor.authorInestrosa Cantín, Nibaldo
dc.date.accessioned2024-02-09T15:39:45Z
dc.date.available2024-02-09T15:39:45Z
dc.date.issued2008
dc.description.abstractBackground: Alzheimer's disease (AD) is the most prevalent neurodegenerative disease in the growing population of elderly people. Synaptic dysfunction is an early manifestation of AD. The cellular mechanism by which β-amyloid peptide (Aβ) affects synapses remains unclear. Aβ oligomers target synapses in cultured rat hippocampal neurons suggesting that they play a key role in the regulation of synapses. Objective: The aim of this work is to study the effect of Aβ oligomers on the central synapses and the possible role of the Wnt signaling pathway in preventing the Aβ effects. Methods: We used rat hippocampal neurons, immunofluorescence and western blot procedures to detect synaptic proteins. Results: Aβ oligomers induced a reduction of the postsynaptic density protein 95 (PSD-95) and the NMDA glutamate receptors. We found that Wnt-5a, a noncanonical Wnt ligand, prevents the decrease triggered by Aβ oligomers in the glutamate receptor and PSD-95. Conclusion: Altogether, our results suggest that Aβ oligomers decrease the synaptic responses by affecting the postsynaptic region at different levels. The Wnt signaling activation prevents synaptic damage induced by Aβ, which raises the possibility of a new therapeutic intervention for the treatment of synaptic changes observed in AD. Copyright © 2008 S. Karger AG.
dc.fechaingreso.objetodigital2024-02-09
dc.fuente.origenScopus
dc.identifier.doi10.1159/000113687
dc.identifier.eissn16602862
dc.identifier.issn16602854 16602862
dc.identifier.pubmedid18322375
dc.identifier.scopusidSCOPUS_ID:0-40449128901
dc.identifier.urihttps://doi.org/10.1159/000113687
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/81325
dc.identifier.wosidWOS:000254109700011
dc.information.autorucFacultad de Ciencias Biológicas; Dinamarca Ceballos, Margarita Constanza; S/I; 16859
dc.information.autorucFacultad de Ciencias Biológicas; Colombres Raby, Marcela; S/I; 19114
dc.information.autorucFacultad de Ciencias Biológicas; Cerpa Nebott ,Waldo Francisco; 0000-0001-7344-0144; 16584
dc.information.autorucFacultad de Ciencias Biológicas; Inestrosa Cantín, Nibaldo; 0000-0003-3118-9726; 26312
dc.issue.numero3-4
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final152
dc.pagina.inicio149
dc.revistaNeurodegenerative Diseases
dc.rightsacceso restringido
dc.subjectβ-Amyloid peptide oligomers
dc.subjectAlzheimer's disease
dc.subjectSynaptic toxicity
dc.subjectWnt signaling pathway
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleβ-amyloid oligomers affect the structure and function of the postsynaptic region: Role of the Wnt signaling pathway
dc.typeartículo
dc.volumen5
sipa.codpersvinculados16859
sipa.codpersvinculados19114
sipa.codpersvinculados16584
sipa.codpersvinculados26312
sipa.trazabilidadScopus;12-10-2021
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