Reactive oxygen species modulate locomotor activity and dopamine extracellular levels induced by amphetamine in rats

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dc.contributor.authorZegers-Delgado, Juan
dc.contributor.authorBlanlot, Camila
dc.contributor.authorCalderon, Florencia
dc.contributor.authorYarur, Hector E.
dc.contributor.authorNovoa, Javier
dc.contributor.authorVega-Quiroga, Ignacio
dc.contributor.authorBastias, Cristian P.
dc.contributor.authorGysling, Katia
dc.date.accessioned2025-01-20T21:04:45Z
dc.date.available2025-01-20T21:04:45Z
dc.date.issued2022
dc.description.abstractThe increase of dopamine (DA) in the reward system is related to the reinforcing effects of drugs of abuse and hyper locomotion induced by psychostimulants. The increase of DA induced by drugs of abuse generates high amounts of ROS by monoamines metabolization. It has been showed that ROS could modulate psychomotor response and reinforcing effects induced by drugs of abuse as cocaine and methamphetamine (METH). The aim of this study is to evaluate the relation of ROS and amphetamine (AMPH). Here, we show that pretreatment of the ROS scavenger 4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPOL) attenuates the induction of locomotion and oxidative stress generated in nucleus accumbens (Nac) by acute AMPH administration. Interestingly, TEMPOL also attenuates the increase of DA induced by AMPH in Nac. Finally, TEMPOL reduces DAT phosphorylation when AMPH is co-infused in Nac synaptosomes. Taking together, our results suggest that ROS modulate AMPH effects in rats.
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.bbr.2022.113857
dc.identifier.eissn1872-7549
dc.identifier.issn0166-4328
dc.identifier.urihttps://doi.org/10.1016/j.bbr.2022.113857
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/93256
dc.identifier.wosidWOS:000821272600004
dc.language.isoen
dc.revistaBehavioural brain research
dc.rightsacceso restringido
dc.subjectAmphetamine
dc.subjectDopamine
dc.subjectOxidative stress
dc.subjectMicrodialysis
dc.subjectNac
dc.subjectVTA
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleReactive oxygen species modulate locomotor activity and dopamine extracellular levels induced by amphetamine in rats
dc.typeartículo
dc.volumen427
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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