Identification of Gap Junctions in the Oviduct and Regulation of Connexins During Development and Sexual Hormones

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dc.contributor.authorHermoso, M.
dc.contributor.authorSáez, Juan Carlos
dc.contributor.authorVillalón, Manuel J.
dc.date.accessioned2017-04-25T19:27:35Z
dc.date.available2017-04-25T19:27:35Z
dc.date.issued1997
dc.description.abstractGap junctions in epithelial cells of the oviduct were identified by immunohistochemistry and Western blotting, Immunohistochemical studies showed that rat, hamster, mouse, and human oviducts contained connexin26 and connexin43 but not connexin32, The content of both connexins in the oviduct depended on the cell type, state of maturation and hormone status, During ontogeny, the epithelial and smooth muscle cells of immature rat oviducts (< 30 days) contained a low amount of connexin43, and connexin26 was undetectable, In mature oviducts (> 30 days), however, connexin26 was detected only in the isthmus and in localized regions of the ampullar epithelial layer, Moreover, at this age, the amount of connexin43 was high in both cell strata throughout the entire organ, During the estrous cycle, levels of connexin43 in the isthmic but not in the ampullar segment were higher in the proestrous and estrous day than at diestrous days, In addition, estrogen treatment produced a significant increase in total and phosphorylated isoforms of connexin43 Levels in oviducts of pregnant rats, The estrogen effect was prevented by the simultaneous administration of progesterone which by itself did not affect the levels of connexin43. The high content of connexins found between oviductal cells as well as their responsiveness to hormone regulation, suggest that gap junctions might be involved in coordinating oviductal cell functions such as smooth muscle contraction and epithelial ciliary beat.
dc.fechaingreso.objetodigital2024-06-25
dc.format.extent9 páginas
dc.fuente.origenWOS
dc.identifier.issn0171-9335
dc.identifier.pubmedidMEDLINE:9309385
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/20539
dc.identifier.wosidWOS:A1997XU40400001
dc.information.autorucFacultad de Ciencias Biológicas; Villalon Bravo, Manuel Jose; S/I; 99264
dc.language.isoen
dc.nota.accesoContenido parcial
dc.revistaEuropean Journal of Cell Biologyes_ES
dc.rightsacceso restringido
dc.subjectintercellular channels
dc.subjectfallopian tube
dc.subjectontogeny
dc.subjectepithelium
dc.subjectCx43
dc.subjectestrogen
dc.subjectprogesterone
dc.subjectINTERCELLULAR COMMUNICATION
dc.subjectPROTEIN CONNEXIN-43
dc.subjectESTROGEN-RECEPTOR
dc.subjectOVUM TRANSPORT
dc.subjectCILIATED CELLS
dc.subjectRAT UTERUS
dc.subjectPROGESTERONE
dc.subjectMYOMETRIUM
dc.subjectEXPRESSION
dc.subjectMECHANISMS
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.subject.otherConexinas - Análisises_ES
dc.subject.otherCélulas epitelialeses_ES
dc.subject.otherTrompas de falopioes_ES
dc.subject.otherProgesteronaes_ES
dc.titleIdentification of Gap Junctions in the Oviduct and Regulation of Connexins During Development and Sexual Hormoneses_ES
dc.typeartículo
sipa.codpersvinculados99913
sipa.codpersvinculados99264
sipa.indexWOS
sipa.indexPubmed
sipa.trazabilidadCarga SIPA;09-01-2024
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