Chemical characterization and microencapsulation of extracellular fungal pigments

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dc.contributor.authorContreras-Machuca, Paulina I.
dc.contributor.authorAvello, Marcia
dc.contributor.authorPastene, Edgar
dc.contributor.authorMachuca, Angela
dc.contributor.authorAranda, Mario
dc.contributor.authorHernandez, Vicente
dc.contributor.authorFernandez, Marcos
dc.date.accessioned2025-01-20T20:22:31Z
dc.date.available2025-01-20T20:22:31Z
dc.date.issued2022
dc.description.abstractIn this work, extracellular colored metabolites obtained from the filamentous fungi Talaromyces australis and Penicillium murcianum, isolated in the Andean-Patagonian native forests of Chile, were studied as prospect compounds to increase the sustainability of cosmetic products. The chemical and antioxidant properties of these natural pigments were characterized and strategies for their microencapsulation were also studied. UHPLC/MS-MS analyses indicated that the predominant metabolites detected in the cultures of P. murcianum were monascin (m/z = 411.15) and monashexenone (m/z = 319.10), while athrorosin H (m/z = 458.20) and damnacanthal (m/z = 281.05) were detected in cultures of T. australis. ORAC tests revealed that P. murcianum's metabolites had the greatest antioxidant properties with values higher than 2000 mu mol of trolox equivalents/g. The fungal metabolites were successfully microencapsulated by ionic gelation into structures made of 1.3% sodium alginate, 0.2% chitosan, and 0.07% hyaluronic acid. The microencapsulation process generated structures of 543.57 +/- 0.13 mu m of mean diameter (d(50)) with an efficiency of 30% for P. murcianum, and 329.59 +/- 0.15 mu m of mean diameter (d(50)) and 40% efficiency, for T. australis. The chemical and biological characterization show the biotechnological potential of these fungal species to obtain pigments with antioxidant activity that could be useful in the cosmetic industry. The encapsulation process enables the production of easy-to-handle dry powder from the fungal metabolites, which could be potentially marketed as a functional cosmetic ingredient.
dc.fuente.origenWOS
dc.identifier.doi10.1007/s00253-022-12255-9
dc.identifier.eissn1432-0614
dc.identifier.issn0175-7598
dc.identifier.urihttps://doi.org/10.1007/s00253-022-12255-9
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/92681
dc.identifier.wosidWOS:000882352500003
dc.issue.numero24
dc.language.isoen
dc.pagina.final8034
dc.pagina.inicio8021
dc.revistaApplied microbiology and biotechnology
dc.rightsacceso restringido
dc.subjectFungal pigments
dc.subjectAzaphilones
dc.subjectAnthraquinoids
dc.subjectMass spectrometry
dc.subjectORAC assay
dc.subjectIonic gelation
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleChemical characterization and microencapsulation of extracellular fungal pigments
dc.typeartículo
dc.volumen106
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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