A 12-month prospective study on the time to hospitalization and clinical management of a cohort of bipolar type I and schizoaffective bipolar patients

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dc.contributor.authorMurru, Andrea
dc.contributor.authorVerdolini, Norma
dc.contributor.authorAnmella, Gerard
dc.contributor.authorPacchiarotti, Isabella
dc.contributor.authorSamalin, Ludovic
dc.contributor.authorAedo, Alberto
dc.contributor.authorUndurraga, Juan
dc.contributor.authorGoikolea, Jose M.
dc.contributor.authorAmann, Benedikt L.
dc.contributor.authorCarvalho, Andre F.
dc.contributor.authorVieta, Eduard
dc.date.accessioned2025-01-23T21:11:11Z
dc.date.available2025-01-23T21:11:11Z
dc.date.issued2019
dc.description.abstractBackground: Schizoaffective disorder, bipolar type (SAD) and bipolar disorder I (BD) present a large clinical overlap. In a 1-year follow-up, we aimed to evaluate days to hospitalization (DTH) and predictors of relapse in a SAD-BD cohort of patients.
dc.description.abstractMethods: A 1-year, prospective, naturalistic cohort study considering DTH as primary outcome and incidence of direct and indirect measures of psychopathological compensation as secondary outcomes. Kaplan-Meyer survival analysis with Log-rank Mantel-Cox test compared BD/SAD subgroups as to DTH. After bivariate analyses, Cox regression was performed to assess covariates possibly associated with DTH in diagnostic subgroups.
dc.description.abstractResults: Of 836 screened patients, 437 were finally included (SAD = 105; BD = 332). Relapse rates in the SAD sample was n = 26 (24.8%) vs. n = 41 (12.3%) in the BD sample (p = 0.002). Mean +/- SD DTH were 312.16 +/- 10.6 (SAD) vs. 337.62 +/- 4.4 (BD) days (p = 0.002). Patients with relapses showed more frequent suicide acts, violent behaviors, and changes in pharmacological treatments (all p < 0.0005) in comparison to patients without relapse. Patients without relapses had significantly higher mean number of treatments at T0 (p = 0.010). Cox regression model relating the association between diagnosis and DTH revealed that BD had higher rates of suicide attempts (HR = 13.0, 95% CI = 4.0-42.0, p < 0.0005), whereas SAD had higher rates of violent behavior during psychotic episodes (HR = 12.0, 95% CI =.3.3-43.5, p > 0.0005).
dc.description.abstractConclusions: SAD patients relapse earlier with higher hospitalization rates and violent behavior during psychotic episodes whereas bipolar patients have more suicide attempts. Psychiatric/psychological follow-up visits may delay hospitalizations by closely monitoring symptoms of self-and hetero-aggression. (C) 2019 Published by Elsevier Masson SAS.
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.eurpsy.2019.06.001
dc.identifier.eissn1778-3585
dc.identifier.issn0924-9338
dc.identifier.urihttps://doi.org/10.1016/j.eurpsy.2019.06.001
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/100891
dc.identifier.wosidWOS:000483706200001
dc.language.isoen
dc.pagina.final8
dc.pagina.inicio1
dc.revistaEuropean psychiatry
dc.rightsacceso restringido
dc.subjectBipolar disorder
dc.subjectSchizoaffective disorder
dc.subjectAggressiveness
dc.subjectSuicide
dc.subjectLongitudinal study
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleA 12-month prospective study on the time to hospitalization and clinical management of a cohort of bipolar type I and schizoaffective bipolar patients
dc.typeartículo
dc.volumen61
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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