Loss of protein tyrosine phosphatase receptor delta PTPRD increases the number of cortical neurons, impairs synaptic function and induces autistic-like behaviors in adult mice

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dc.article.number57
dc.catalogadorpau
dc.contributor.authorCortés, Bastián I.
dc.contributor.authorMeza, Rodrigo C.
dc.contributor.authorAncatén-González, Carlos
dc.contributor.authorArdiles, Nicolás M.
dc.contributor.authorAránguiz, María-Ignacia
dc.contributor.authorTomita, Hideaki
dc.contributor.authorKaplan, David R.
dc.contributor.authorCornejo, Francisca
dc.contributor.authorNunez-Parra, Alexia
dc.contributor.authorMoya, Pablo R.
dc.contributor.authorChávez, Andrés E.
dc.contributor.authorCancino, Gonzalo I.
dc.date.accessioned2024-07-01T16:47:27Z
dc.date.available2024-07-01T16:47:27Z
dc.date.issued2024
dc.date.updated2024-06-23T00:03:46Z
dc.description.abstractBackground: The brain cortex is responsible for many higher-level cognitive functions. Disruptions during cortical development have long-lasting consequences on brain function and are associated with the etiology of brain disorders. We previously found that the protein tyrosine phosphatase receptor delta Ptprd, which is genetically associated with several human neurodevelopmental disorders, is essential to cortical brain development. Loss of Ptprd expression induced an aberrant increase of excitatory neurons in embryonic and neonatal mice by hyper-activating the pro-neurogenic receptors TrkB and PDGFRβ in neural precursor cells. However, whether these alterations have long-lasting consequences in adulthood remains unknown. Results: Here, we found that in Ptprd+/- or Ptprd-/- mice, the developmental increase of excitatory neurons persists through adulthood, affecting excitatory synaptic function in the medial prefrontal cortex. Likewise, heterozygosity or homozygosity for Ptprd also induced an increase of inhibitory cortical GABAergic neurons and impaired inhibitory synaptic transmission. Lastly, Ptprd+/- or Ptprd-/- mice displayed autistic-like behaviors and no learning and memory impairments or anxiety. Conclusions: These results indicate that loss of Ptprd has long-lasting effects on cortical neuron number and synaptic function that may aberrantly impact ASD-like behaviors.
dc.fechaingreso.objetodigital2024-07-01
dc.fuente.origenBiomed Central
dc.identifier.citationBiological Research. 2024 Jun 18;57(1):40
dc.identifier.doi10.1186/s40659-024-00522-0
dc.identifier.urihttps://doi.org/10.1186/s40659-024-00522-0
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/86918
dc.identifier.wosidWOS:001249607600001
dc.information.autorucFacultad de Ciencias Biológicas; Aránguiz, María-Ignacia; S/I; 1027836
dc.information.autorucFacultad de Ciencias Biológicas; Cancino, Gonzalo I.; S/I; 17709
dc.issue.numero40
dc.language.isoen
dc.nota.accesocontenido completo
dc.revistaBiological Research
dc.rightsacceso abierto
dc.rights.holderThe Author(s)
dc.rights.licenseCC BY 4.0 ATTRIBUTION 4.0 INTERNATIONAL
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleLoss of protein tyrosine phosphatase receptor delta PTPRD increases the number of cortical neurons, impairs synaptic function and induces autistic-like behaviors in adult mice
dc.typeartículo
sipa.codpersvinculados1027836
sipa.codpersvinculados17709
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