Cardiovascular and ventilatory acclimatization induced by chronic intermittent hypoxia

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dc.contributor.authorIturriaga, R
dc.contributor.authorRey, S
dc.contributor.authorDel Río, R
dc.date.accessioned2025-01-21T01:07:14Z
dc.date.available2025-01-21T01:07:14Z
dc.date.issued2005
dc.description.abstractPatients with obstructive sleep apnea (OSA) show augmentes ventilatory, sympathetic and cardiovascular responses to hypoxia. The facilitatory effect of chronic intermittent hypoxia (CIH) on the hypoxic ventilatory response has been attributed to a potentiation of the carotid body (CB) chemosensory response to hypoxia. However. it is a matter of debate whether the effects induced by CIH oil ventilatory responses to hypoxia are due to all enhanced CB activity. Recently, we studied the effects of short cyclic hypoxic episodes oil cat cardiorespiratory reflexes, heart rate variability, and CB chemosensory activity. Cats were exposed to cyclic hypoxic episodes repealed during 8 hours for 4 days. Our results showed that CIH selcectively enhanced ventilatory and carotid chemosensory responses to acute hypoxia. Exposure to CIH did not increase basal arterial pressure, heart-rate. or-the changes induced by acute hypoxia. However. the spectral analysis of heart rate variability of CIH cats showed a marked increase of the low/high frequency ratio and an increased variability in the low frequency band of heart rate variability, similar to what is observed ill OSA patients. Thus, it is likely that the enhanced CB reactivity to hypoxia may contribute to the augmented ventilatory response to hypoxia.
dc.fuente.origenWOS
dc.identifier.eissn0717-6287
dc.identifier.issn0716-9760
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/96296
dc.identifier.wosidWOS:000236190300004
dc.issue.numero4
dc.language.isoen
dc.pagina.final340
dc.pagina.inicio335
dc.revistaBiological research
dc.rightsacceso restringido
dc.subjectventilatory acclimatization
dc.subjectcarotid body
dc.subjectchemosensory activity
dc.subjectintermittent hypoxia
dc.subjectobstructive sleep apnea
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleCardiovascular and ventilatory acclimatization induced by chronic intermittent hypoxia
dc.typeartículo
dc.volumen38
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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