<i>Malva sylvestris</i> derivatives as inhibitors of HIV-1 BaL infection

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dc.contributor.authorBenso, Bruna
dc.contributor.authorRosalen, Pedro Luiz
dc.contributor.authorPasetto, Silvana
dc.contributor.authorSalome Marquezin, Maria Carolina
dc.contributor.authorFreitas-Blanco, Veronica
dc.contributor.authorMurata, Ramiro Mendonca
dc.date.accessioned2025-01-20T23:56:35Z
dc.date.available2025-01-20T23:56:35Z
dc.date.issued2021
dc.description.abstractThe emphasis of the present study is to evaluate a natural product and the potential microbicide activity using a dual chamber infection method. Malva sylvestris extracts and fractions were screened for anti-HIV activity by measuring the virus-antibody neutralization. Plant extracts with strong antiviral activity working in nanomolar or picomolar range can be used to enhance the activity of synthetic compounds and work as anti-HIV agents. The aqueous fraction (AF) of M. sylvestris demonstrated antiviral activity in a model with epithelial and blood cell lines. The AF showed an effective antiviral potential on the TZM-bl cells with reduction scores higher than 60% of infectivity. Quantification of p24 in the supernatant of the co-culture model demonstrated a reduction in the number of viral particles after AF treatment (p < 0.05). Cytokines were quantified and all signaling inflammatory markers; IL1-alpha, IL-beta, IL-6, IL-8 and GM-CSF (p < 0.05) were modulated by positive control and AF treatments. In particular, IL-6 had lower levels of expression in Malva groups when compared to the Zidovudine positive control group. Natural occurring derivatives of M. sylvestris demonstrated to work inhibiting reverse transcriptase enzyme action. M. sylvestris contains highly potential anti-HIV-1 BaL components and may be considered a potential source for new formulations in the development of topical microbicides.
dc.fuente.origenWOS
dc.identifier.doi10.1080/14786419.2019.1619720
dc.identifier.eissn1478-6427
dc.identifier.issn1478-6419
dc.identifier.urihttps://doi.org/10.1080/14786419.2019.1619720
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/95163
dc.identifier.wosidWOS:000482426500001
dc.issue.numero6
dc.language.isoen
dc.pagina.final1069
dc.pagina.inicio1064
dc.revistaNatural product research
dc.rightsacceso restringido
dc.subjectMalva sylvestris
dc.subjectHIV infections
dc.subjectinflammation
dc.subjectanti-infective agents
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.title<i>Malva sylvestris</i> derivatives as inhibitors of HIV-1 BaL infection
dc.typeartículo
dc.volumen35
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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