EFFECT OF MORPHINE ON THE CLEARANCE OF ENDOGENOUS CREATININE AND BLOOD CLINICAL CHEMICALS IN THE RAT

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dc.contributor.authorHUIDOBRO, F
dc.contributor.authorCROXATTO, R
dc.contributor.authorHUIDOBROTORO, JP
dc.date.accessioned2025-01-23T19:44:34Z
dc.date.available2025-01-23T19:44:34Z
dc.date.issued1979
dc.description.abstractThe effect of morphine on urine and blood serum concentration of Na+, K+, Cl- and other chemicals was determined using Sprague Dawley rats, previously hydrated with 50 ml/kg of 0.5% NaCl to provoke an increased diuresis. Morphine caused about a 90% decrease in the urine concentration of Na+, K+ and Cl-. This reduction in the urine electrolyte excretion was associated with a small but significant increase in the concentration of the blood Na+ and Cl-. The anti-diuresis and the decrease in urine electrolytes caused by morphine was paralleled by a 50% reduction of the endogenous creatinine clearance. An acute dose of 7.5 mg/kg morphine i.p. did not alter the concentration of 13 other clinical blood chemicals with the exception of urea. After 18 h of morphine pellet implantation, a significant increase was found in the blood urea and in the activity of serum transaminases. Lactic dehydrogenases isoenzymes 1 and 2 were significantly increased in the blood of rats chronically administered with morphine.
dc.fuente.origenWOS
dc.identifier.issn0003-9780
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/100078
dc.identifier.wosidWOS:A1979GR94500004
dc.issue.numero1
dc.language.isoen
dc.pagina.final41
dc.pagina.inicio31
dc.revistaArchives internationales de pharmacodynamie et de therapie
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleEFFECT OF MORPHINE ON THE CLEARANCE OF ENDOGENOUS CREATININE AND BLOOD CLINICAL CHEMICALS IN THE RAT
dc.typeartículo
dc.volumen237
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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