Clinical characteristics, anticoagulation therapy, and short-term outcomes of neonatal cerebral sinovenous thrombosis: a cross-sectional study from a Chilean center

Simple item page
dc.catalogadorvdr
dc.contributor.authorDuk Fonseca, Nasser Andrés
dc.contributor.authorHernández Chávez, Marta Isabel
dc.contributor.authorBravo Morales, Sebastián Ignacio
dc.contributor.authorLópez Espejo, Mauricio Alejandro
dc.date.accessioned2025-06-04T16:31:25Z
dc.date.available2025-06-04T16:31:25Z
dc.date.issued2023
dc.description.abstractPurpose: Cerebral sinovenous thrombosis (SVT) is a rare but severe condition, with neonates having the highest incidence among pediatric patients. The underlying conditions contributing to SVT are heterogeneous, and although anticoagulation therapy (ACT) is safe and potentially beneficial, the evidence supporting its effectiveness on neurological outcomes is lacking. This study analyzed the association of clinical-demographic characteristics and ACT in the acute setting with vital-neurological outcomes at discharge in neonates with SVT. Methodology: This cross-sectional study utilized secondary data from 30 neonates with SVT confirmed by MRI/MRV at a single center in Chile between 2005 and 2021. Penalized maximum likelihood logistic regression models were conducted to calculate adjusted odds ratios. Results: The median gestational age, weight, and age of diagnostic were 38 weeks (IQR 37–39), 3141 grams (IQR 2579–3478), and 15 days (IQR 8.7–27.5), respectively. All patients had diffuse neurological signs. Acute seizures and focal deficits were detected in 12 (40%) and 1 (3.3%) cases. At discharge, 15 (50%) patients had a neurological deficit, and 7 (23.3%) died. The frequency of ACT use was higher between 2013 and 2021 than between 2005 and 2012 (8% vs. 2%, Fisher's exact test, p 0.05). Adjusted for demographic and clinical variables, ACT was negatively associated with adverse vital or neurological outcomes (OR 0.18, 95% CI 0.03–1.00). Conclusions: ACT increased its use over time. Our results suggest that ACT in neonates with SVT is associated with better neurological outcomes at discharge and lower in-hospital case fatality. Further follow-up is needed to establish long-term associations.
dc.fechaingreso.objetodigital2025-06-04
dc.format.extent14 páginas
dc.fuente.origenORCID
dc.identifier.doi10.21203/rs.3.rs-2856281/v1
dc.identifier.urihttps://doi.org/10.21203/rs.3.rs-2856281/v1
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/104581
dc.information.autorucEscuela de Medicina; Duk Fonseca, Nasser Andrés; S/I; 1095666
dc.information.autorucEscuela de Medicina; Hernández Chávez, Marta Isabel; 0000-0002-4238-8969; 55673
dc.information.autorucEscuela de Medicina; Bravo Morales, Sebastián Ignacio; 0000-0003-0998-8433; 13431
dc.information.autorucEscuela de Medicina; López Espejo, Mauricio Alejandro; 0000-0003-4278-9188; 209731
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final14
dc.pagina.inicio1
dc.rightsacceso abierto
dc.rights.licenseCC BY 4.0 Attribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectCerebrovascular disorders
dc.subjectInfant
dc.subjectIntracranial thrombosis
dc.subjectNewborn
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleClinical characteristics, anticoagulation therapy, and short-term outcomes of neonatal cerebral sinovenous thrombosis: a cross-sectional study from a Chilean center
dc.typepreprint
sipa.codpersvinculados209731
sipa.codpersvinculados1095666
sipa.codpersvinculados55673
sipa.codpersvinculados13431
sipa.trazabilidadORCID;2025-06-03
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
90105424-5c02-4c2a-a618-6628c6ec0a0e.pdf
Size:
246.77 KB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Artículos de revistas