A 13 KDA FRAGMENT IS RESPONSIBLE FOR THE HYDROPHOBIC AGGREGATION OF BRAIN G4 ACETYLCHOLINESTERASE

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dc.contributor.authorFUENTES, ME
dc.contributor.authorROSENBERRY, TL
dc.contributor.authorINESTROSA, NC
dc.date.accessioned2025-01-23T19:24:22Z
dc.date.available2025-01-23T19:24:22Z
dc.date.issued1988
dc.description.abstractProteinase K treatment of the bovine brain acetylcholinesterase (AChE) releases a hydrophobic fragment of 13 kDa, which is entirely responsible entirely responsible for the aggregation of the G4 AChE in the absence of detergent. This observation provides evidence that the 13 kDa fragment, which comes from a previously identified 20 kDA subunit, is directly involved in the attachment of the G4 AChE to brain membranes. A model for the organization of the different sub-domains of the hydrophobic anchor of the G4 AChE is presented.
dc.fuente.origenWOS
dc.identifier.eissn1470-8728
dc.identifier.issn0264-6021
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/99347
dc.identifier.wosidWOS:A1988R493000053
dc.issue.numero3
dc.language.isoen
dc.pagina.final1050
dc.pagina.inicio1047
dc.revistaBiochemical journal
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleA 13 KDA FRAGMENT IS RESPONSIBLE FOR THE HYDROPHOBIC AGGREGATION OF BRAIN G4 ACETYLCHOLINESTERASE
dc.typeartículo
dc.volumen256
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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