EARLY AXONAL REGENERATION - REPRESSION BY SCHWANN-CELLS AND A PROTEASE

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dc.contributor.authorTAPIA, M
dc.contributor.authorINESTROSA, NC
dc.contributor.authorALVAREZ, J
dc.date.accessioned2025-01-21T01:35:03Z
dc.date.available2025-01-21T01:35:03Z
dc.date.issued1995
dc.description.abstractWe have proposed that mature Schwann cells and an extracellular protease repress the sprouting response of axons. To test this hypothesis, we destroyed all cells by freezing a short span of the rat sciatic nerve or inhibited proteases with subperineurial injections of aprotinin, and a crush was made to induce the sprouting response. In unconditioned or in vehicle-injected nerves, axons began to elongate at a constant rate after a delay of about 1 day. The freezing of the nerve distal to the crush obliterated the delay, but the rate of elongation did not change. A similar pattern was observed when the nerve segment was conditioned with aprotinin for 2 days prior to the crush. These effects were abolished when a short untreated segment was left between crush and conditioned region of the nerve. The electron microscopy of the nerve and the immunolocalization of the growth-associated protein (GAP-43) were consistent with the enhanced regrowth observed in conditioned nerves. Our findings support the notion that Schwann cells repress the onset of regeneration and that a local protease is involved. (C) 1995 Academic Press, Inc.
dc.fuente.origenWOS
dc.identifier.eissn1090-2430
dc.identifier.issn0014-4886
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/97634
dc.identifier.wosidWOS:A1995QN05600013
dc.issue.numero1
dc.language.isoen
dc.pagina.final132
dc.pagina.inicio124
dc.revistaExperimental neurology
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleEARLY AXONAL REGENERATION - REPRESSION BY SCHWANN-CELLS AND A PROTEASE
dc.typeartículo
dc.volumen131
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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