EFFECT OF INTRANIGRAL MN-2+ ON STRIATAL AND NIGRAL SYNTHESIS AND LEVELS OF DOPAMINE AND COFACTOR

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dc.contributor.authorDANIELS, AJ
dc.contributor.authorABARCA, J
dc.date.accessioned2025-01-23T19:22:35Z
dc.date.available2025-01-23T19:22:35Z
dc.date.issued1991
dc.description.abstractA single injection of manganese chloride into the rat substantia nigra caused a significant and reversible drop in nigral and striatal dopamine and cofactor content ipsilateral to the lesion. Maximal decrease, in both tissues, was observed 60 days after the lesion, and showed complete recovery at 90 days. In vivo striatal tyrosine hydroxylation and GTP cyclohydrolase activities were also decreased maximally at 60 days and were recovered by 90 days after the lesion. No effects were observed on the side contralateral to the injection.
dc.fuente.origenWOS
dc.identifier.issn0892-0362
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/99062
dc.identifier.wosidWOS:A1991GR68600002
dc.issue.numero5
dc.language.isoen
dc.pagina.final487
dc.pagina.inicio483
dc.revistaNeurotoxicology and teratology
dc.rightsacceso restringido
dc.subjectMANGANESE NEUROTOXICITY
dc.subjectSTRIATAL DOPAMINE SYNTHESIS
dc.subjectTETRAHYDROBIOPTERIN COFACTOR
dc.subjectTYROSINE HYDROXYLATION
dc.subjectGTP CYCLOHYDROLASE
dc.subjectNIGRO-STRIATAL DOPAMINERGIC PATHWAY
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleEFFECT OF INTRANIGRAL MN-2+ ON STRIATAL AND NIGRAL SYNTHESIS AND LEVELS OF DOPAMINE AND COFACTOR
dc.typeartículo
dc.volumen13
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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