Integration of nutrigenomics, melatonin, serotonin and inflammatory cytokines in the pathophysiology of pregnancy-specific urinary incontinence in women with gestational diabetes mellitus

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dc.article.number166737
dc.contributor.authorFranca D.C.H.
dc.contributor.authorFranca E.L.
dc.contributor.authorSobrevia L.
dc.contributor.authorBarbosa A.M.P.
dc.contributor.authorHonorio-Franca A.C.
dc.contributor.authorRudge M.V.C.
dc.date.accessioned2025-05-01T10:31:13Z
dc.date.available2025-05-01T10:31:13Z
dc.date.issued2023
dc.description.abstract© 2023 Elsevier B.V.Gestational diabetes mellitus is an important public health problem and has been associated with the development of pregnancy-specific urinary incontinence. The interaction is related to hyperglycemia, and inflammatory and hormonal patterns, which favor functional alterations in different organs and systems. Several genes associated with human diseases have been identified and partially characterized. Most of these genes are known to cause monogenic diseases. However, about 3 % of diseases do not fit the monogenic theory due to the complex interactions between multiple genes and environmental factors, as in chronic metabolic diseases such as diabetes. The nutritional, immunological, and hormonal patterns associated with changes in maternal metabolism may influence and contribute to greater susceptibility to urinary tract disorders. However, early systematic reviews have not yielded consistent findings for these associations. This literature review summarizes important new findings from integrating nutrigenomics, hormones, and cytokines in women with Gestational diabetes mellitus and pregnancy-specific urinary incontinence. Changes in maternal metabolism due to hyperglycemia can generate an inflammatory environment with increased inflammatory cytokines. This environment modulated by inflammation can alter tryptophan uptake through food and thus influence the production of serotonin and melatonin. As these hormones seem to have protective effects against smooth muscle dysfunction and to restore the impaired contractility of the detrusor muscle, it is assumed that these changes may favor the onset of urinary incontinence specific to pregnancy.
dc.description.funderPost-Graduate Program Botucatu Medical School UNESP
dc.description.funderUniversity of Groningen
dc.description.funderFAPESP
dc.description.funderCoordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.description.funderFondo Nacional de Desarrollo Científico y Tecnológico
dc.description.funderConselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.funderPontificia Universidad Católica de Chile
dc.format.extent13 páginas
dc.fuente.origenScopus
dc.identifier.doi10.1016/j.bbadis.2023.166737
dc.identifier.eisbn978-1-5106-5352-8
dc.identifier.eissn1542-7714
dc.identifier.isbn978-1-5106-5351-1
dc.identifier.issn1879260X 09254439
dc.identifier.pubmedid40243597
dc.identifier.scieloidS0718-69242020000300109
dc.identifier.scopusidSCOPUS_ID:85158873676
dc.identifier.urihttps://doi.org/10.1016/j.bbadis.2023.166737
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/103728
dc.identifier.wosidWOS:001053204000001
dc.information.autorucEscuela de Medicina; Sobrevia Luarte Luis Alberto; 0000-0001-5802-2243; 1002656
dc.information.autorucEscuela de Medicina; Sobrevia Luarte Luis Alberto; 0000-0001-5802-2243; 1002656
dc.issue.numero8
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final2134
dc.pagina.inicio2124
dc.relation.ispartofInternational Conference on Intelligent User Interfaces (30a. : 2025)
dc.revistaBiochimica et Biophysica Acta - Molecular Basis of Disease
dc.rightsacceso restringido
dc.subjectEpigenetic
dc.subjectHormones
dc.subjectHyperglycemia
dc.subjectImmunomodulation
dc.subjectInvoluntary loss of urine
dc.subject.ddc510
dc.subject.deweyMatemática física y químicaes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleIntegration of nutrigenomics, melatonin, serotonin and inflammatory cytokines in the pathophysiology of pregnancy-specific urinary incontinence in women with gestational diabetes mellitus
dc.typeartículo
dc.volumen1869
sipa.codpersvinculados1002656
sipa.codpersvinculados1002656
sipa.indexScopus
sipa.trazabilidadCarga WOS-SCOPUS;01-05-2025
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