Oligodendrocytes damage in Alzheimer's disease

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dc.contributor.authorRoth, AD
dc.contributor.authorRamírez, G
dc.contributor.authorAlarcón, R
dc.contributor.authorvon Bernhardi, R
dc.date.accessioned2025-01-21T01:07:14Z
dc.date.available2025-01-21T01:07:14Z
dc.date.issued2005
dc.description.abstractResearch on Alzheimer's disease (AD) focuses mainly on neuronal death and synaptic impairment induced by beta-Amyloid peptide (A beta), events at least partially mediated by astrocyte and microglia activation. However, substantial white matter damage and its consequences on brain function warrant the study of oligodendrocytes' compromise in AD and discuss some experimental data indicative of A beta toxicity in culture. We observed that 1 mu M of fibrilogenic A beta peptide damages of astrocytes reduced the A beta-induced damage. This agrees with our previous results showing an astrocyte-mediated protective effect over A beta-induced damage on hippocampal cells and modulation of the activation of microglial cells in culture. Oligodendrocytes protection by astrocytes could be. either by reduction of A beta peptide damages oligodendrocytes in vitro: while pro-inflammatory molecules (1 mu g/ ml LPS + 1 ng/ml IFN gamma) or the presence of astrocytes reduced the A beta-induced damage on hippocampal cells and modulation of the activation of microglial cells in culture. Oligodendrocytes protection by astrocytes could be either by reduction of A beta fibrilogenesis/deposition or prevention of oxidative damage. Likewise, the decrease of A beta-induced damge by proinflammatory molecules could reflect the production of trophic factors by activated oligodendrocytes and/or a metabolic activation as observed during myelination. Considering the association of inflammation with neurodegenerative disease. oligodendrocytes impairement in AD patients could potentiate cell damage under pathological conditions.
dc.fuente.origenWOS
dc.identifier.eissn0717-6287
dc.identifier.issn0716-9760
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/96298
dc.identifier.wosidWOS:000236190300011
dc.issue.numero4
dc.language.isoen
dc.pagina.final387
dc.pagina.inicio381
dc.revistaBiological research
dc.rightsacceso restringido
dc.subjectcell death
dc.subjectglial cells
dc.subjectpro-inflammatory cytokines
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleOligodendrocytes damage in Alzheimer's disease
dc.typeartículo
dc.volumen38
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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