Positive cystic duct margin at index cholecystectomy in incidental gallbladder cancer is an important negative prognosticator

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dc.contributor.authorVega, Eduardo A.
dc.contributor.authorVinuela, Eduardo
dc.contributor.authorSanhueza, Marcel
dc.contributor.authorMege, Rosemarie
dc.contributor.authorCaracci, Mario
dc.contributor.authorDiaz, Cristian
dc.contributor.authorDiaz, Alfonso
dc.contributor.authorOkuno, Masayuki
dc.contributor.authorJoechle, Katharina
dc.contributor.authorGoumard, Claire
dc.contributor.authorChun, Yun Shin
dc.contributor.authorTzeng, Ching-Wei D.
dc.contributor.authorLee, Jeffrey E.
dc.contributor.authorVauthey, Jean-Nicolas
dc.contributor.authorConrad, Claudius
dc.date.accessioned2025-01-23T21:12:55Z
dc.date.available2025-01-23T21:12:55Z
dc.date.issued2019
dc.description.abstractBackground: Prognostic factors following index-cholecystectomy in patients with incidental gallbladder cancer (IGBC) are poorly understood. The aim of this study was to assess the value of the initial cystic duct margin status as a prognosticator factor and to aid in clinical decision making to move forward with curative intent oncologic extended resection (OER).
dc.description.abstractMethods: This retrospective study included patients with IGBC who underwent subsequent OER with curative intent at 2 centers (USA and Chile) between 1999 and 2016., Patients with and without evidence of residual cancer (RC) at OER were included. Pathologic features were examined, and predictors of overall survival (OS) were analyzed.
dc.description.abstractResults: The study included 179 patients. Thirty-three patients (17%) had a positive cystic duct margin at the index cholecystectomy. Forty-two patients (23%) underwent resection of the common bile duct. OS was significantly worse in the patients with a positive cystic duct margin at index cholecystectomy (OS rates at 5 years, 34% vs 57%; p = 0.032). Following multivariate analysis, only a positive cystic duct margin at index cholecystectomy was predictive of worse OS in patients with no evidence of residual cancer (RC) at OER (hazard ratio, 1.7 95%Cl 1.04-2.78; p = 0.034).
dc.description.abstractConclusions: A positive cystic duct margin at index-cholecystectomy is a strong independent predictor of worse OS even if no further cancer is found at OER. In patients with positive cystic duct margin and no RC at OER common bile duct resection leads to improved outcomes. (C) 2019 Published by Elsevier Ltd.
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.ejso.2019.01.013
dc.identifier.eissn1532-2157
dc.identifier.issn0748-7983
dc.identifier.urihttps://doi.org/10.1016/j.ejso.2019.01.013
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/100984
dc.identifier.wosidWOS:000470941000021
dc.issue.numero6
dc.language.isoen
dc.pagina.final1068
dc.pagina.inicio1061
dc.revistaEjso
dc.rightsacceso restringido
dc.subjectGallbladder neoplasms
dc.subjectCystic duct margin
dc.subjectCholecystectomy
dc.subjectSurvival
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titlePositive cystic duct margin at index cholecystectomy in incidental gallbladder cancer is an important negative prognosticator
dc.typeartículo
dc.volumen45
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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