Evidences for mineralocorticoid excess in essential hypertensionExceso de mineralocorticoides en hipertensos esenciales: Enfoque clínico-diagnóstico

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dc.article.number106217
dc.contributor.authorCortés P. P.
dc.contributor.authorFardella B. C.
dc.contributor.authorOestreicher C. E.
dc.contributor.authorGac E. H.
dc.contributor.authorMosso G. L.
dc.contributor.authorSoto M. J.
dc.contributor.authorForadori C. A.
dc.contributor.authorClaverie R. X.
dc.contributor.authorAhuad N. J.
dc.contributor.authorMontero L. J.
dc.contributor.authorFardella B. C.
dc.contributor.otherNCD Risk Factor Collaboration (NCD-RisC)
dc.date.accessioned2024-08-15T08:00:21Z
dc.date.available2024-08-15T08:00:21Z
dc.date.issued2000
dc.description.abstractBackground: Primary hyperaldosteronism is more frequent among subjects with essential hypertension than previously thought. The prevalence, according to local and international evidence could fluctuate between 9 and 10%. Aim: To investigate if subjects with essential hypertension have different aldosterone and renin plasma levels than normotensive subjects. Patients and methods: One hundred twenty five subjects with essential hypertension, not receiving medications for at least two weeks prior to the study and 168 age and sex matched normotensive controls were studied. Blood was drawn between 9 and 10 AM during a sodium free diet to determine plasma aldosterone, plasma renin activity and potassium. Results: Plasma aldosterone was higher in hypertensive subjects than controls (11.6 ± 7.6 and 9.9 ± 5.1 ng/dl respectively; p=0.04). Plasma renin activity was lower in hypertensives than controls (1.42 ± 1.28 and 1.88 ± 1.39 ng/ml/h respectively; p<0.001). Thus, plasma aldosterone/plasma renin activity ratio was higher in hypertensives (13.8 ± 13.5 and 8.3 ± 7.8; p<0.001). A pathological ratio was defined as over 25, corresponding to the mean plus two standard deviations of the control group. Primary hyperaldosteronism was found in 5/125 hypertensives (4%) and 1/168 normotensive subject (0.6%). None had hypokalemia. Conclusions: Subjects with essential hypertension have higher plasma aldosterone and lower plasma renin activity than normal controls. A plasma aldosterone/plasma renin activity over 25 was defined as abnormal.
dc.description.funderANID through FONDECYT
dc.format.extent16 páginas
dc.fuente.origenScopus
dc.identifier.doi10.1016/S0140-6736(01)05509-X
dc.identifier.eissn1814-9332
dc.identifier.issn00349887
dc.identifier.pubmedid11349499
dc.identifier.scopusidSCOPUS_ID:0034281126
dc.identifier.urihttps://doi.org/10.1016/S0140-6736(01)05509-X
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/87465
dc.identifier.wosidWOS:001274878600001
dc.information.autorucFacultad de Medicina; Mosso Gomez, Lorena Montserrat; S/I; 88201
dc.issue.numero7
dc.language.isoes
dc.nota.accesoSin adjunto
dc.pagina.final961
dc.pagina.inicio955
dc.relation.ispartof92nd Meeting and Expo of the Endocrine Society (ENDO 2010), JUN 19-22, 2010, San Diego, CA
dc.revistaRevista Medica de Chile
dc.rightsregistro bibliográfico
dc.subjectAldosterone
dc.subjectHyperaldosteronism
dc.subjectHypertension
dc.subject.ddc550
dc.subject.deweyCiencias de la tierraes_ES
dc.titleEvidences for mineralocorticoid excess in essential hypertensionExceso de mineralocorticoides en hipertensos esenciales: Enfoque clínico-diagnóstico
dc.typeartículo
dc.volumen128
sipa.codpersvinculados88201
sipa.indexScopus
sipa.indexPubmed
sipa.trazabilidadCarga WOS-SCOPUS;15-08-2024
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