Amyloid precursor protein fragment and acetylcholinesterase increase with cell confluence and differentiation in a neuronal cell line

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dc.contributor.authorBronfman, FC
dc.contributor.authorFernandez, HL
dc.contributor.authorInestrosa, NC
dc.date.accessioned2025-01-21T01:33:43Z
dc.date.available2025-01-21T01:33:43Z
dc.date.issued1996
dc.description.abstractThis study addresses the developmental regulation of amyloid precursor protein (APP) fragments comprising the amyloid-beta peptide (A beta) and the amyloid-promoting factor acetylcholinesterase (AChE) in a mouse neuronal cell line (Neuro-2a). Results indicate that a 35-kDa amyloidogenic fragment of APP and the major molecular forms of AChE (G(1) and G(4)) in Neuro-2a cells significantly increase with increasing levels of cell confluence. The foregoing molecules undergo further increases when neuroblastoma cells differentiate in the presence of dibutyryl cAMP. In contrast, a 17-kDa fragment of APP and butyrylcholinesterase mere not affected by cell confluence or differentiation. These findings are the first to indicate that a selective A beta-containing fragment of APP is subject to developmental regulation. Moreover, our data show that the 35-kDa fragment and AChE forms respond in parallel to the same developmental stimuli, i.e., cell confluence and differentiation. This points to the existence of a functional relationship between both molecules, a notion that is consistent with the potential role that has been ascribed to AChE in both APP processing and the formation of amyloid deposits in Alzheimer's brains. (C) 1996 Academic Press, Inc.
dc.fuente.origenWOS
dc.identifier.issn0014-4827
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/97460
dc.identifier.wosidWOS:A1996VV20700012
dc.issue.numero1
dc.language.isoen
dc.pagina.final99
dc.pagina.inicio93
dc.revistaExperimental cell research
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleAmyloid precursor protein fragment and acetylcholinesterase increase with cell confluence and differentiation in a neuronal cell line
dc.typeartículo
dc.volumen229
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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