Extracellular vesicle interactions with the external and internal exposome in mediating carcinogenesis

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dc.article.number101039
dc.contributor.authorKalita-de Croft P.
dc.contributor.authorSharma S.
dc.contributor.authorSalomon C.
dc.contributor.authorSobrevia L.
dc.contributor.authorSobrevia L.
dc.contributor.authorSobrevia L.
dc.contributor.authorSobrevia L.
dc.contributor.authorSobrevia L.
dc.contributor.authorSalomon C.
dc.date.accessioned2025-05-01T10:32:32Z
dc.date.available2025-05-01T10:32:32Z
dc.date.issued2021
dc.description.abstract© 2021The influence of environmental factors on an individual, from conception onwards, is defined as the exposome. It can be categorized into the external exposome, which includes external factors such as air pollution, chemical contaminants, and diet, and the internal exposome, which is unique to an individual, and involves age, physiology, and their genetic profile. The effect of external exposures on the internal exposome, or genetic profile, can be determined through omics analyses. However, this is often compromised due to low sample quantity and cost. Therefore, identification of other factors that can provide an insight into the cellular profile of an individual, provides an exciting avenue, and an emerging field is that of extracellular vesicles (EVs). Recently, our understanding of how cells can communicate with each other has shifted to recognise the role of EVs. EVs are secreted by all living cells, and have been identified in all biological fluids studied so far. They transport bioactive molecules (e.g., proteins, miRNAs, and DNA), and their release can be regulated by the cellular microenvironment. Analysis of EVs in respond to environmental factors might provide novel insights into the role of tumour EVs in carcinogenesis. Not only will EVs give some insight into the tumour cells themselves but they will also provide a better understanding of how cells communicate with one another, contributing to cancer progression. Moreover, characterising the content and functions of tumour-derived EVs has the potential to overcome the current challenges to improve cancer patient outcomes. For example, the identification of EVs targets for therapeutic interventions and tumour EVs biomarkers could facilitate the development of early screening for several cancers. The aim of this review, thus, is to discuss the overall role of EVs in response to the various external and internal signals in cancer. We will specifically highlight the biogenesis, secretion, and content of EVs in response to oncogenic transformation and metabolic regulators in cancer.
dc.description.funderDonald & Joan Wilson Foundation Ltd
dc.description.funderMedical Research Future Fund
dc.description.funderOvarian Cancer Research Foundation
dc.description.funderNHMRC
dc.description.funderUniversity of Groningen
dc.description.funderFONDECYT
dc.description.funderPontificia Universidad Cat?lica de Chile
dc.description.funderLion Medical Research Foundation
dc.format.extent345 páginas
dc.fuente.origenScopus
dc.identifier.doi10.1016/j.mam.2021.101039
dc.identifier.eisbn978-1-0716-1534-8
dc.identifier.eissn18729452
dc.identifier.isbn978-1-0716-1533-1
dc.identifier.issn18729452 00982997
dc.identifier.pubmedid34479261
dc.identifier.scieloidS0718-69242020000300109
dc.identifier.scopusidSCOPUS_ID:85116765113
dc.identifier.urihttps://doi.org/10.1016/j.mam.2021.101039
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/103864
dc.identifier.wosidWOS:000809763700008
dc.information.autorucEscuela de Medicina; Sobrevia Luarte Luis Alberto; 0000-0001-5802-2243; 1002656
dc.information.autorucEscuela de Medicina; Sobrevia Luarte Luis Alberto; 0000-0001-5802-2243; 1002656
dc.issue.numero1
dc.language.isoen
dc.nota.accesoSin adjunto
dc.pagina.final345
dc.pagina.inicio324
dc.publisherHUMANA PRESS INC
dc.relation.ispartofMolecular Aspects of Medicine
dc.revistaMolecular Aspects of Medicine
dc.rightsAcceso cerrado
dc.subjectCancer
dc.subjectExosomes
dc.subjectExposome
dc.subjectExtracellular vesicles
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleExtracellular vesicle interactions with the external and internal exposome in mediating carcinogenesis
dc.typeartículo
dc.volumen20
sipa.codpersvinculados1002656
sipa.codpersvinculados1002656
sipa.indexScopus
sipa.indexWOS
sipa.trazabilidadCarga WOS-SCOPUS;01-05-2025
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