LPA-induced expression of CCN2 in muscular fibro/adipogenic progenitors (FAPs): Unraveling cellular communication networks

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dc.contributor.authorCordova-Casanova, Adriana
dc.contributor.authorCruz-Soca, Meilyn
dc.contributor.authorGallardo, Felipe S.
dc.contributor.authorFaundez-Contreras, Jennifer
dc.contributor.authorBock-Pereda, Alexia
dc.contributor.authorChun, Jerold
dc.contributor.authorVio, Carlos P.
dc.contributor.authorCasar, Juan Carlos
dc.contributor.authorBrandan, Enrique
dc.date.accessioned2025-01-20T16:16:26Z
dc.date.available2025-01-20T16:16:26Z
dc.date.issued2024
dc.description.abstractCellular Communication Network Factor 2, CCN2, is a profibrotic cytokine implicated in physiological and pathological processes in mammals. The expression of CCN2 is markedly increased in dystrophic muscles. Interestingly, diminishing CCN2 genetically or inhibiting its function improves the phenotypes of chronic muscular fibrosis in rodent models. Elucidating the cell-specific mechanisms behind the induction of CCN2 is a fundamental step in understanding its relevance in muscular dystrophies. Here, we show that the small lipids LPA and 2S-OMPT induce CCN2 expression in fibro/adipogenic progenitors (FAPs) through the activation of the LPA1 receptor and, to a lower extent, by also the LPA6 receptor. These cells show a stronger induction than myoblasts or myotubes. We show that the LPA/LPARs axis requires ROCK kinase activity and organized actin cytoskeleton upstream of YAP/TAZ signaling effectors to upregulate CCN2 levels, suggesting that mechanical signals are part of the mechanism behind this process. In conclusion, we explored the role of the LPA/LPAR axis on CCN2 expression, showing a strong cytoskeletal-dependent response in muscular FAPs.
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.matbio.2024.05.001
dc.identifier.eissn1569-1802
dc.identifier.issn0945-053X
dc.identifier.urihttps://doi.org/10.1016/j.matbio.2024.05.001
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/90547
dc.identifier.wosidWOS:001241466300001
dc.language.isoen
dc.pagina.final46
dc.pagina.inicio36
dc.revistaMatrix biology
dc.rightsacceso restringido
dc.subjectLPA
dc.subjectCCN2
dc.subjectFAPs
dc.subjectStiffness
dc.subjectMuscular fibrosis
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleLPA-induced expression of CCN2 in muscular fibro/adipogenic progenitors (FAPs): Unraveling cellular communication networks
dc.typeartículo
dc.volumen130
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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