THE PARADOXICAL RESPONSE OF GROWTH-HORMONE (GH) TO THYROTROPIN-RELEASING-HORMONE (TRH) IN CONSTITUTIONALLY TALL CHILDREN INVOLVES A CHOLINERGIC PATHWAY

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dc.contributor.authorARTEAGA, E
dc.contributor.authorVALENZUELAA, P
dc.contributor.authorCATTANI, A
dc.contributor.authorDELVALLE, M
dc.date.accessioned2025-01-23T19:23:41Z
dc.date.available2025-01-23T19:23:41Z
dc.date.issued1989
dc.description.abstractTo investigate whether or not a cholinergic pathway is involved in the paradoxical response of GH to TRH in constitutionally tall children, we studied 8 healthy prepubertal children aged 42/12 - 7 10/12 yr, whose heights were over the 95th percentile of the NCHS tables. We defined as "paradoxical" a GH increment greater than 5 ng/ml in response to TRH. Five out of 8 children showed a paradoxical response of GH to TRH (mean GH peak after TRH of 10.7 .+-. 1.1 ng/ml). Pretreatment with atropine (0.01 mg/kg IM 30 min prior to the TRH administration) abolished the TRH induced GH rise (peak GH after TRH of 1.5 .+-. 1.0 ng/ml, p < 0.01) but did not modify the TSH response (peak TSH after TRH: basal conditions 8.7 .+-. 0.8 .mu.U/ml, post atropine: 9.5 .+-. 1.4 .mu.U/ml, p > 0.05). Our results demonstrate that a cholinergic pathway is involved in the paradoxical response of GH to TRH in constitutionally tall children.
dc.fuente.origenWOS
dc.identifier.eissn1720-8386
dc.identifier.issn0391-4097
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/99249
dc.identifier.wosidWOS:A1989AU73200006
dc.issue.numero8
dc.language.isoen
dc.pagina.final548
dc.pagina.inicio543
dc.revistaJournal of endocrinological investigation
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleTHE PARADOXICAL RESPONSE OF GROWTH-HORMONE (GH) TO THYROTROPIN-RELEASING-HORMONE (TRH) IN CONSTITUTIONALLY TALL CHILDREN INVOLVES A CHOLINERGIC PATHWAY
dc.typeartículo
dc.volumen12
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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