FATTY-ACID OXIDATION BY HUMAN-LIVER PEROXISOMES
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Date
1979
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Abstract
A cyanide insensitive fatty acid oxidation system was detected in human liver by subcellular fractionation in Metrizamide continuous density gradients and was localized in peroxisomes. Fatty acyl-CoA oxidase, its characteristic enzyme, acts maximally on C12-C18 saturated fatty acids and oleoyl-CoA and requires FAD. These results, and the already established properties of the system in rat liver support its potential contribution to lipid metabolism and to the hypolipidemic effect of Clofibrate and related drugs in humans.