Characterization of an <i>Agarophyton chilense</i> Oleoresin Containing PPARγ Natural Ligands with Insulin-Sensitizing Effects in a C57Bl/6J Mouse Model of Diet-Induced Obesity and Antioxidant Activity in <i>Caenorhabditis elegans</i>

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dc.contributor.authorPinto, Claudio
dc.contributor.authorRaquel Ibanez, Maria
dc.contributor.authorLoyola, Gloria
dc.contributor.authorLeon, Luisa
dc.contributor.authorSalvatore, Yasmin
dc.contributor.authorGonzalez, Carla
dc.contributor.authorBarraza, Victor
dc.contributor.authorCastaneda, Francisco
dc.contributor.authorAldunate, Rebeca
dc.contributor.authorContreras-Porcia, Loretto
dc.contributor.authorFuenzalida, Karen
dc.contributor.authorBronfman, Francisca C.
dc.date.accessioned2025-01-20T22:17:40Z
dc.date.available2025-01-20T22:17:40Z
dc.date.issued2021
dc.description.abstractThe biomedical potential of the edible red seaweed Agarophyton chilense (formerly Gracilaria chilensis) has not been explored. Red seaweeds are enriched in polyunsaturated fatty acids and eicosanoids, which are known natural ligands of the PPAR gamma nuclear receptor. PPAR gamma is the molecular target of thiazolidinediones (TZDs), drugs used as insulin sensitizers to treat type 2 diabetes mellitus. Medical use of TZDs is limited due to undesired side effects, a problem that has triggered the search for selective PPAR gamma modulators (SPPARMs) without the TZD side effects. We produced Agarophyton chilense oleoresin (Gracilex(R)), which induces PPAR gamma activation without inducing adipocyte differentiation, similar to SPPARMs. In a diet-induced obesity model of male mice, we showed that treatment with Gracilex(R) improves insulin sensitivity by normalizing altered glucose and insulin parameters. Gracilex(R) is enriched in palmitic acid, arachidonic acid, oleic acid, and lipophilic antioxidants such as tocopherols and beta-carotene. Accordingly, Gracilex(R) possesses antioxidant activity in vitro and increased antioxidant capacity in vivo in Caenorhabditis elegans. These findings support the idea that Gracilex(R) represents a good source of natural PPAR gamma ligands and antioxidants with the potential to mitigate metabolic disorders. Thus, its nutraceutical value in humans warrants further investigation.
dc.fuente.origenWOS
dc.identifier.doi10.3390/nu13061828
dc.identifier.eissn2072-6643
dc.identifier.urihttps://doi.org/10.3390/nu13061828
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/94555
dc.identifier.wosidWOS:000666235100001
dc.issue.numero6
dc.language.isoen
dc.revistaNutrients
dc.rightsacceso restringido
dc.subjectnatural lipids
dc.subjectseaweeds
dc.subjectAgarophyton chilense
dc.subjectPPAR gamma
dc.subjectinsulin resistance
dc.subjectobesity
dc.subjectantioxidants
dc.subjectCaenorhabditis elegans
dc.subjectnutraceuticals
dc.subjectGracilex(R)
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleCharacterization of an <i>Agarophyton chilense</i> Oleoresin Containing PPARγ Natural Ligands with Insulin-Sensitizing Effects in a C57Bl/6J Mouse Model of Diet-Induced Obesity and Antioxidant Activity in <i>Caenorhabditis elegans</i>
dc.typeartículo
dc.volumen13
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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