Intestinal protozoa in returning travellers: a GeoSentinel analysis from 2007 to 2019

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dc.contributor.authorWeitzel, Thomas
dc.contributor.authorBrown, Ashley
dc.contributor.authorLibman, Michael
dc.contributor.authorPerret, Cecilia
dc.contributor.authorHuits, Ralph
dc.contributor.authorChen, Lin
dc.contributor.authorLeung, Daniel T.
dc.contributor.authorLeder, Karin
dc.contributor.authorConnor, Bradley A.
dc.contributor.authorMenendez, Marta D.
dc.contributor.authorAsgeirsson, Hilmir
dc.contributor.authorSchwartz, Eli
dc.contributor.authorSalvador, Fernando
dc.contributor.authorMalvy, Denis
dc.contributor.authorSaio, Mauro
dc.contributor.authorNorman, Francesca F.
dc.contributor.authorAmatya, Bhawana
dc.contributor.authorDuvignaud, Alexandre
dc.contributor.authorVaughan, Stephen
dc.contributor.authorGlynn, Marielle
dc.contributor.authorAngelo, Kristina M.
dc.date.accessioned2025-01-20T17:08:57Z
dc.date.available2025-01-20T17:08:57Z
dc.date.issued2024
dc.description.abstractBackground Prolonged diarrhoea is common amongst returning travellers and is often caused by intestinal protozoa. However, the epidemiology of travel-associated illness caused by protozoal pathogens is not well described. Methods We analysed records of returning international travellers with illness caused by Giardia duodenalis, Cryptosporidium spp., Cyclospora cayetanensis or Cystoisospora belli, reported to the GeoSentinel Network during January 2007-December 2019. We excluded records of travellers migrating, with an unascertainable exposure country, or from GeoSentinel sites that were not located in high-income countries. Results There were 2517 cases, 82.3% giardiasis (n = 2072), 11.4% cryptosporidiosis (n = 287), 6.0% cyclosporiasis (n = 150) and 0.3% cystoisosporiasis (n = 8). Overall, most travellers were tourists (64.4%) on long trips (median durations: 18-30 days). Cryptosporidiosis more frequently affected people < 18 years (13.9%) and cyclosporiasis affected people >= 40 years (59.4%). Giardiasis was most frequently acquired in South Central Asia (45.8%) and sub-Saharan Africa (22.6%), cryptosporidiosis in sub-Saharan Africa (24.7%) and South-Central Asia (19.5%), cyclosporiasis in South East Asia (31.3%) and Central America (27.3%), and cystoisosporiasis in sub-Saharan Africa (62.5%). Cyclosporiasis cases were reported from countries of uncertain endemicity (e.g. Cambodia) or in countries with no previous evidence of this parasite (e.g. French Guiana). The time from symptom onset to presentation at a GeoSentinel site was the longest amongst travellers with giardiasis (median: 30 days). Over 14% of travellers with cryptosporidiosis were hospitalized. Conclusions This analysis provides new insights into the epidemiology and clinical significance of four intestinal protozoa that can cause morbidity in international travellers. These data might help optimize pretravel advice and post-travel management of patients with travel-associated prolonged gastrointestinal illnesses. This analysis reinforces the importance of international travel-related surveillance to identify sentinel cases and areas where protozoal infections might be undetected or underreported.
dc.fuente.origenWOS
dc.identifier.doi10.1093/jtm/taae010
dc.identifier.eissn1708-8305
dc.identifier.issn1195-1982
dc.identifier.urihttps://doi.org/10.1093/jtm/taae010
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/90998
dc.identifier.wosidWOS:001163891100001
dc.issue.numero4
dc.language.isoen
dc.revistaJournal of travel medicine
dc.rightsacceso restringido
dc.subjectTravel
dc.subjectgastrointestinal diseases
dc.subjectGiardia
dc.subjectCryptosporidium
dc.subjectCyclospora
dc.subjectsurveillance
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleIntestinal protozoa in returning travellers: a GeoSentinel analysis from 2007 to 2019
dc.typeartículo
dc.volumen31
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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