Multiple motion encoding in phase-contrast MRI: A general theory and application to elastography imaging

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dc.contributor.authorHerthum, Helge
dc.contributor.authorCarrillo, Hugo
dc.contributor.authorOsses, Axel
dc.contributor.authorUribe, Sergio
dc.contributor.authorSack, Ingolf
dc.contributor.authorBertoglio, Cristobal
dc.date.accessioned2025-01-20T21:07:46Z
dc.date.available2025-01-20T21:07:46Z
dc.date.issued2022
dc.description.abstractWhile MRI allows to encode the motion of tissue in the magnetization's phase, it remains yet a challenge to obtain high fidelity motion images due to wraps in the phase for high encoding efficiencies. Therefore, we propose an optimal multiple motion encoding method (OMME) and exemplify it in Magnetic Resonance Elastography (MRE) data. OMME is formulated as a non-convex least-squares problem for the motion using an arbitrary number of phase-contrast measurements with different motion encoding gradients (MEGs). The mathematical properties of OMME are proved in terms of standard deviation and dynamic range of the motion's estimate for arbitrary MEGs combination which are confirmed using synthetically generated data. OMME's performance is assessed on MRE data from in vivo human brain experiments and compared to dual encoding strategies. The unwrapped images are further used to reconstruct stiffness maps and compared to the ones obtained using conventional unwrapping methods. OMME allowed to successfully combine several MRE phase images with different MEGs, outperforming dual encoding strategies in either motion-to-noise ratio (MNR) or number of successfully reconstructed voxels with good noise stability. This lead to stiffness maps with greater resolution of details than obtained with conventional unwrapping methods. The proposed OMME method allows for a flexible and noise robust increase in the dynamic range and thus provides wrap-free phase images with high MNR. In MRE, the method may be especially suitable when high resolution images with high MNR are needed. (c) 2022 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license ( http://creativecommons.org/licenses/by/4.0/ )
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.media.2022.102416
dc.identifier.eissn1361-8423
dc.identifier.issn1361-8415
dc.identifier.urihttps://doi.org/10.1016/j.media.2022.102416
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/93435
dc.identifier.wosidWOS:000793644400005
dc.language.isoen
dc.revistaMedical image analysis
dc.rightsacceso restringido
dc.subjectPhase-contrast MRI
dc.subjectMultiple motion encoding
dc.subjectMagnetic resonance elastography
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleMultiple motion encoding in phase-contrast MRI: A general theory and application to elastography imaging
dc.typeartículo
dc.volumen78
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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